4DX2
Crystal structure of the human TRPV4 ankyrin repeat domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transient receptor potential cation channel subfamily V member 4 | polymer | 259 | 29456.7 | 2 | UniProt (Q9HBA0) Pfam (PF00023) | Homo sapiens (human) | TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC |
| 2 | C (A) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 3 | D (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 4 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 149 - 397 (UniProt: Q9HBA0)
| PDB | External Database | Details |
|---|---|---|
| Met 148 | - | initiating methionine |
| Ala 398 | - | expression tag |
| Ala 399 | - | expression tag |
| Ala 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58913.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 779.4 | |
| All* | Total formula weight | 59692.9 |
