4DX1

Crystal structure of the human TRPV4 ankyrin repeat domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transient receptor potential cation channel subfamily V member 4	polymer	259	29456.7	2	UniProt (Q9HBA0) Pfam (PF00023) In PDB	Homo sapiens (human)	TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC
2	A, B	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 149 - 397 (UniProt: Q9HBA0)

PDB	External Database	Details
Met 148	-	initiating methionine
Ala 398	-	expression tag
Ala 399	-	expression tag
Ala 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58913.5
Non-Polymers*	Number of molecules	6
	Total formula weight	566.9
All*	Total formula weight	59480.4

*Water molecules are not included.