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4DX1

Crystal structure of the human TRPV4 ankyrin repeat domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 501
ChainResidue
AARG269
AGLY270
ATYR281
ATYR283
AGLU286
AARG320

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 502
ChainResidue
APRO298
AHIS299
AILE300
ALYS177
ALYS251
AGLN297

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 503
ChainResidue
AARG206
ALYS251
AHIS252

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 B 501
ChainResidue
BARG269
BGLY270
BTYR281
BTYR283
BGLU286
BARG320

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 B 502
ChainResidue
BGLN297
BPRO298
BHIS299
BILE300

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 B 503
ChainResidue
BHIS299
BASN302

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:22702953, ECO:0007744|PDB:4DX2
ChainResidueDetails
ALYS192
BARG248
ALYS197
AASN201
ATYR236
AARG248
BLYS192
BLYS197
BASN201
BTYR236

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:A0A1D5PXA5
ChainResidueDetails
AARG249
AASN296
ALYS344
BARG249
BASN296
BLYS344

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9EPK8
ChainResidueDetails
ATYR253
BTYR253

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PDB entries from 2024-11-06

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