4DX1

Crystal structure of the human TRPV4 ankyrin repeat domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	ARG269
A	GLY270
A	TYR281
A	TYR283
A	GLU286
A	ARG320

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 502

Chain	Residue
A	PRO298
A	HIS299
A	ILE300
A	LYS177
A	LYS251
A	GLN297

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 503

Chain	Residue
A	ARG206
A	LYS251
A	HIS252

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 501

Chain	Residue
B	ARG269
B	GLY270
B	TYR281
B	TYR283
B	GLU286
B	ARG320

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 502

Chain	Residue
B	GLN297
B	PRO298
B	HIS299
B	ILE300

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 B 503

Chain	Residue
B	HIS299
B	ASN302

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	58
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22702953","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DX2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A1D5PXA5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9EPK8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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