4DVR

Crystal structure of YU2 gp120 core in complex with Fab 48d and NBD-557

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	Envelope glycoprotein gp120	polymer	313	34918.6	1	UniProt (P35961) Pfam (PF00516)	Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)	Env polyprotein,Env polyprotein,Env polyprotein
2	B (L)	Fab 48d Light chain	polymer	212	23092.6	1		Homo sapiens (human)
3	C (H)	Fab 48d Heavy chain	polymer	219	23386.1	1		Homo sapiens (human)
4	D, E, F, G, H... (G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
5	K (G)	N-(4-bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide	non-polymer		382.3	1	Chemie (0LY)
6	L, M, N (G, L, H)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

G: 83 - 123 (UniProt: P35961)
G: 199 - 301 (UniProt: P35961)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G: 324 - 492 (UniProt: P35961)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	81397.3
Non-Polymers*	Number of molecules	8
	Total formula weight	1930.8
All*	Total formula weight	83328.1

*Water molecules are not included.