4DRB

The crystal structure of FANCM bound MHF complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D, E, G... (A, B, D, E, G...)	Centromere protein S	polymer	120	14325.7	6	UniProt (Q8N2Z9) Pfam (PF15630)	Homo sapiens (human)	CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1, FANCM-interacting histone fold protein 1, Fanconi anemia-associated polypeptide of 16 kDa
2	C, F, I (C, F, I)	Fanconi anemia group M protein	polymer	141	16845.7	3	UniProt (Q8IYD8) Pfam (PF16783)	Homo sapiens (human)	Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog
3	J, K, L, M, N... (J, K, L, M, N...)	Centromere protein X	polymer	84	9348.5	6	UniProt (A8MT69) Pfam (PF09415)	Homo sapiens (human)	CENP-X, FANCM-interacting histone fold protein 2, Fanconi anemia-associated polypeptide of 10 kDa, Retinoic acid-inducible gene D9 protein homolog, Stimulated by retinoic acid gene 13 protein homolog
4	AA, BA, CA, DA, P... (L, M, N, O, A...)	water	water		18.0	120	Chemie (HOH)

Sequence modifications

A, B, D, E, G, H: 1 - 114 (UniProt: Q8N2Z9)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

C, F, I: 661 - 800 (UniProt: Q8IYD8)

PDB	External Database	Details
Gly 660	-	expression tag

J, K, L, M, N, O: 1 - 81 (UniProt: A8MT69)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	192582.2
All*	Total formula weight	192582.2

*Water molecules are not included.