4DJC
1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calmodulin | polymer | 152 | 17124.8 | 1 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | Homo sapiens (human) | CaM |
| 2 | B (B) | Sodium channel protein type 5 subunit alpha | polymer | 35 | 4121.9 | 1 | UniProt (Q14524) | Homo sapiens (human) | HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5 |
| 3 | C, D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | G, H, I, J, K... (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 9 | Chemie (IPA) | |||
| 5 | P, Q (A, B) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 1 - 149 (UniProt: P62158)
B: 1491 - 1522 (UniProt: Q14524)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 1488 | - | expression tag |
| Asn 1489 | - | expression tag |
| Ala 1490 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21246.7 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 701.2 | |
| All* | Total formula weight | 21947.9 |
