4DJC

1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Calmodulin	polymer	152	17124.8	1	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) In PDB	Homo sapiens (human)	CaM
2	B	Sodium channel protein type 5 subunit alpha	polymer	35	4121.9	1	UniProt (Q14524) In PDB	Homo sapiens (human)	HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5
3	A	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4	A	ISOPROPYL ALCOHOL	non-polymer		60.1	9	Chemie (IPA)
5		water	water		18.0	161	Chemie (HOH)

Sequence modifications

A: 1 - 149 (UniProt: P62158)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

B: 1491 - 1522 (UniProt: Q14524)

PDB	External Database	Details
Ser 1488	-	expression tag
Asn 1489	-	expression tag
Ala 1490	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21246.7
Non-Polymers*	Number of molecules	13
	Total formula weight	701.2
All*	Total formula weight	21947.9

*Water molecules are not included.