4D6U
Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL | polymer | 480 | 52796.4 | 1 | UniProt (P31800) Pfam (PF00675) Pfam (PF05193) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 1, CORE PROTEIN I, UBIQUINOL-CYTOCHROME- C REDUCTASE COMPLEX CORE PROTEIN 1 |
| 2 | B (B) | CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL | polymer | 453 | 48203.4 | 1 | UniProt (P23004) Pfam (PF00675) Pfam (PF05193) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 2, CORE PROTEIN II, UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN 2 |
| 3 | C, M (C, P) | CYTOCHROME B | polymer | 379 | 42620.3 | 2 | UniProt (P00157) Pfam (PF00033) Pfam (PF00032) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 3, COMPLEX III SUBUNIT III, CYTOCHROME B-C1 COMPLEX SUBUNIT 3, UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CYTOCHROME B SUBUNIT |
| 4 | D, N (D, Q) | CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL | polymer | 325 | 35343.8 | 2 | UniProt (P00125) Pfam (PF02167) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 4, COMPLEX III SUBUNIT IV, CYTOCHROME B-C1 COMPLEX SUBUNIT 4, UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CYTOCHROME C1 SUBUNIT, CYTOCHROME C-1, CYTOCHROME BC1 |
| 5 | E, I, O (E, I, R) | CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL | polymer | 274 | 29586.8 | 3 | UniProt (P13272) Pfam (PF00355) Pfam (PF09165) Pfam (PF02921) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 5, CYTOCHROME B-C1 COMPLEX SUBUNIT 5, RIESKE IRON-SULFUR PROTEIN, RISP, UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, COMPLEX III SUBUNIT IX, UBIQUINOL-CYTOCHROME C REDUCTASE 8 KDA PROTEIN |
| 6 | F, P (F, S) | CYTOCHROME B-C1 COMPLEX SUBUNIT 7 | polymer | 111 | 13502.4 | 2 | UniProt (P00129) Pfam (PF02271) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 7, COMPLEX III SUBUNIT VII, QP-C, UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KDA PROTEIN |
| 7 | G, Q (G, T) | CYTOCHROME B-C1 COMPLEX SUBUNIT 8 | polymer | 82 | 9737.2 | 2 | UniProt (P13271) Pfam (PF02939) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 8, COMPLEX III SUBUNIT VIII, UBIQUINOL- CYTOCHROME C REDUCTASE COMPLEX 9.5 KDA PROTEIN, UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C |
| 8 | H, R (H, U) | CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL | polymer | 91 | 10638.7 | 2 | UniProt (P00126) Pfam (PF02320) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 6, COMPLEX III SUBUNIT VIII, CYTOCHROME C1 NON-HEME 11 KDA PROTEIN, MITOCHONDRIAL HINGE PROTEIN, UBIQUINOL- CYTOCHROME C REDUCTASE COMPLEX 11 KDA PROTEIN |
| 9 | J, T (J, W) | CYTOCHROME B-C1 COMPLEX SUBUNIT 9 | polymer | 64 | 7469.6 | 2 | UniProt (P00130) Pfam (PF05365) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 9, COMPLEX III SUBUNIT X, CYTOCHROME C1 NON-HEME 7 KDA PROTEIN, UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.2 KDA PROTEIN |
| 10 | K (N) | CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL | polymer | 480 | 52768.4 | 1 | UniProt (P31800) Pfam (PF00675) Pfam (PF05193) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 1, CORE PROTEIN I, UBIQUINOL-CYTOCHROME- C REDUCTASE COMPLEX CORE PROTEIN 1 |
| 11 | L (O) | CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL | polymer | 453 | 48204.4 | 1 | UniProt (P23004) Pfam (PF00675) Pfam (PF05193) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 2, CORE PROTEIN II, UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN 2 |
| 12 | S (V) | CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL | polymer | 274 | 29572.8 | 1 | UniProt (P13272) Pfam (PF09165) Pfam (PF02921) Pfam (PF00355) | BOS TAURUS (CATTLE) | COMPLEX III SUBUNIT 5, CYTOCHROME B-C1 COMPLEX SUBUNIT 5, RIESKE IRON-SULFUR PROTEIN, RISP, UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, COMPLEX III SUBUNIT IX, UBIQUINOL-CYTOCHROME C REDUCTASE 8 KDA PROTEIN |
| 13 | JA, KA, U, V (P, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 14 | LA, W (P, C) | 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol | non-polymer | 425.8 | 2 | Chemie (G8U) | |||
| 15 | AA, BA, CA, FA, GA... (D, E, F, N, P...) | PHOSPHATE ION | non-polymer | 95.0 | 9 | Chemie (PO4) | |||
| 16 | EA, NA, QA, Y (D, P, Q, C) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 4 | Chemie (PEE) | |||
| 17 | OA, Z (Q, D) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 18 | DA, HA, PA, UA (D, G, Q, T) | CARDIOLIPIN | non-polymer | 1464.0 | 4 | Chemie (CDL) | |||
| 19 | RA (R) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 1 | Chemie (FES) | |||
| 20 | SA (R) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
F, S: 0 - 110 (UniProt: P00129)
N: -33 - 446 (UniProt: P31800)
O: -13 - 439 (UniProt: P23004)
V: 1 - 274 (UniProt: P13272)
| PDB | External Database | Details |
|---|---|---|
| Asp 56 | Asn 57 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 445 | Arg 479 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 305 | Gln 319 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 64 | Leu 64 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 558930.2 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 14509.5 | |
| All* | Total formula weight | 573439.7 |
