Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4D6U

Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005750	cellular_component	mitochondrial respiratory chain complex III
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005750	cellular_component	mitochondrial respiratory chain complex III
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0070469	cellular_component	respirasome
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0070469	cellular_component	respirasome
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0070469	cellular_component	respirasome
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005750	cellular_component	mitochondrial respiratory chain complex III
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0046872	molecular_function	metal ion binding
I	0051537	molecular_function	2 iron, 2 sulfur cluster binding
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
O	0004222	molecular_function	metalloendopeptidase activity
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006508	biological_process	proteolysis
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005750	cellular_component	mitochondrial respiratory chain complex III
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0022904	biological_process	respiratory electron transport chain
P	0031966	cellular_component	mitochondrial membrane
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	0048039	molecular_function	ubiquinone binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0009055	molecular_function	electron transfer activity
Q	0020037	molecular_function	heme binding
Q	0046872	molecular_function	metal ion binding
Q	0070469	cellular_component	respirasome
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0016491	molecular_function	oxidoreductase activity
R	0046872	molecular_function	metal ion binding
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding
R	0070469	cellular_component	respirasome
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0070469	cellular_component	respirasome
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0070469	cellular_component	respirasome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0070469	cellular_component	respirasome
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005750	cellular_component	mitochondrial respiratory chain complex III
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
V	0016020	cellular_component	membrane
V	0016491	molecular_function	oxidoreductase activity
V	0046872	molecular_function	metal ion binding
V	0051537	molecular_function	2 iron, 2 sulfur cluster binding
V	0070469	cellular_component	respirasome
V	1902600	biological_process	proton transmembrane transport
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005750	cellular_component	mitochondrial respiratory chain complex III
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0070469	cellular_component	respirasome

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM C 501

Chain	Residue
C	GLN44
C	GLY130
C	LEU133
C	PRO134
C	HIS182
C	PHE183
C	PRO186
C	ILE45
C	GLY48
C	LEU49
C	LEU51
C	ALA52
C	VAL66
C	ARG80
C	HIS83

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM C 502

Chain	Residue
C	TRP31
C	GLY34
C	LEU37
C	HIS97
C	ARG100
C	SER106
C	TRP113
C	GLY116
C	VAL117
C	LEU119
C	HIS196
C	LEU200
C	SER205
C	ASN206
C	G8U503

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE G8U C 503

Chain	Residue
C	PHE18
C	LEU21
C	TRP31
C	SER35
C	ILE42
C	LEU197
C	HIS201
C	SER205
C	PHE220
C	ASP228
C	HEM502

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 504

Chain	Residue
A	SER439
A	PHE442
C	HIS221

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEE C 505

Chain	Residue
C	TRP30
C	TYR95
C	ARG100
C	TYR103
C	TYR104
C	PHE276
C	MET316
C	TRP326
C	VAL329
C	LEU332
C	TYR358
G	CDL501

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEC D 501

Chain	Residue
D	VAL36
D	CYS37
D	CYS40
D	HIS41
D	ALA108
D	PRO110
D	ILE116
D	ARG120
D	TYR126
D	PHE153
D	ILE158
D	GLY159
D	MET160
D	PRO163

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 D 502

Chain	Residue
D	PO4504

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 D 504

Chain	Residue
D	PO4502
E	SER56

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CDL D 505

Chain	Residue
C	SER29
C	ASN32
C	LEU36
C	LYS227
C	LEU230
C	LEU234
D	LEU216
D	TYR220
D	LYS223
D	ARG224
D	LYS231
G	ASN36
G	ARG40
G	CDL501

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEE D 506

Chain	Residue
C	MET240
D	HIS200
D	MET204
D	LYS207
E	TYR49
E	ALA50
E	ASN53
E	VAL54

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 E 501

Chain	Residue
A	PHE442
E	TYR37
E	THR40

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 F 501

Chain	Residue
F	TYR93
O	ARG134
O	TRP135
F	ARG49

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CDL G 501

Chain	Residue
C	SER29
C	TRP30
C	PEE505
D	CDL505
F	GLN72
G	ARG40
G	THR41
G	CYS44

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 N 501

Chain	Residue
N	PHE442
R	TYR37
R	THR40

site_id	BC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM P 501

Chain	Residue
P	GLN44
P	ILE45
P	GLY48
P	LEU49
P	ALA52
P	VAL66
P	ARG80
P	HIS83
P	ALA84
P	ALA127
P	GLY130
P	LEU133
P	PRO134
P	HIS182
P	PHE183
P	PRO186

site_id	BC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM P 502

Chain	Residue
P	TRP31
P	GLY34
P	LEU37
P	PHE90
P	LEU94
P	HIS97
P	ARG100
P	SER106
P	PHE109
P	TRP113
P	GLY116
P	VAL117
P	LEU119
P	LEU120
P	HIS196
P	LEU200
P	SER205
P	ASN206

site_id	BC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE G8U P 503

Chain	Residue
P	ALA17
P	PHE18
P	LEU21
P	SER35
P	ILE42
P	ALA193
P	MET194
P	LEU197
P	HIS201
P	SER205
P	PHE220
P	ASP228

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 P 504

Chain	Residue
N	SER439
N	PHE442
P	HIS221

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEE P 505

Chain	Residue
P	TRP30
P	TYR95
P	TYR103
P	TYR104
P	PHE276
P	MET316
P	GLN322
P	TRP326
P	VAL329
P	LEU332
S	SER69
S	GLN72
T	CDL501

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEC Q 501

Chain	Residue
Q	VAL36
Q	CYS37
Q	CYS40
Q	HIS41
Q	LEU109
Q	PRO111
Q	ARG120
Q	TYR126
Q	LEU131
Q	PHE153
Q	GLY159
Q	MET160

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDL Q 505

Chain	Residue
P	SER29
P	LEU36
P	LYS227
Q	TYR220
Q	LYS223
Q	ARG224
Q	LYS231
S	MET70
S	ARG71
T	ASN36
T	ARG40
T	CDL501

site_id	CC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEE Q 506

Chain	Residue
P	ILE229
P	ILE236
Q	HIS200
Q	MET204
Q	LYS207
Q	MET212
R	TYR49
R	ALA50
R	ASN53
R	VAL54
R	GLN57
W	ASP36

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES R 501

Chain	Residue
R	CYS139
R	HIS141
R	LEU142
R	CYS144
R	CYS158
R	HIS161
R	SER163
R	PRO175

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL R 502

Chain	Residue
C	PHE168
R	LYS94
R	ILE136

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 S 501

Chain	Residue
B	ARG134
S	PRO51
S	TYR93

site_id	CC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CDL T 501

Chain	Residue
P	SER28
P	SER29
P	TRP30
P	ILE92
P	MET96
P	PEE505
Q	CDL505
S	GLN72
T	ARG40
T	THR41

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77
O	GLY54-THR77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
V	SER79-SER103
P	TRP77-VAL98
P	TRP113-LEU133
P	PHE178-LEU198
P	ILE226-ALA246
P	LEU288-HIS308
P	LEU320-GLY340
P	TYR347-PRO367
O	LYS185
O	LYS236
U	LYS72
C	ILE226-ALA246
C	LEU288-HIS308
C	LEU320-GLY340
C	TYR347-PRO367
P	PHE33-MET53

site_id	SWS_FT_FI2
Number of Residues	36
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
V	LYS104-MET140
N	LYS214
F	LYS95
S	LYS18
S	LYS82
S	LYS95

site_id	SWS_FT_FI3
Number of Residues	133
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
V	SER141-GLY274
W	ASN47-GLU63
S	LYS77
S	LYS87

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3, ECO:0007744\|PDB:1BGY

Chain	Residue	Details
V	CYS217
I	SER241
R	CYS139
R	HIS141
R	CYS158
R	HIS161
R	SER163
V	HIS219
V	CYS236
V	HIS239
V	SER241
I	CYS217
I	HIS219
I	CYS236
I	HIS239

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3, ECO:0007744\|PDB:1BGY

Chain	Residue	Details
D	HIS41
Q	HIS41

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3

Chain	Residue	Details
D	MET160
Q	MET160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)