4D0Z
GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 | polymer | 571 | 64824.7 | 6 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) | HOMO SAPIENS (HUMAN) | POLYPEPTIDE GALNAC TRANSFERASE 2, GALNAC-T2, PP-GANTASE 2, PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE 2, UDP-GALNAC\: POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, POLYPEPTIDE GALNAC-TRANSFERASE T2 |
| 2 | G, H (X, Y) | PEPTIDE | polymer | 6 | 548.6 | 2 | UniProt (by SIFTS) (Q6FI18) | HOMO SAPIENS (HUMAN) | |
| 3 | GB, HA, HB, I, IA... (E, C, F, A, D...) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 4 | AA, AB, BA, BB, CA... (B, E, A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 37 | Chemie (EDO) | |||
| 5 | EB, FA, KA, T (E, B, D, A) | 2-acetamido-2-deoxy-5-thio-alpha-D-galactopyranose | non-polymer | 237.3 | 4 | Chemie (BBK) | |||
| 6 | FB, GA, IB, JA, U... (E, C, F, D, A...) | (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | non-polymer | 623.4 | 6 | Chemie (HWU) | |||
| 7 | JB, KB, LB, MB, NB... (A, B, C, D, E...) | water | water | 18.0 | 633 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 571 (UniProt: Q10471)
| PDB | External Database | Details |
|---|---|---|
| Asp 516 | Asn 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 390045.4 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 7315.8 | |
| All* | Total formula weight | 397361.2 |
