Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4D0Z

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005795	cellular_component	Golgi stack
A	0006486	biological_process	protein glycosylation
A	0006493	biological_process	protein O-linked glycosylation
A	0016020	cellular_component	membrane
A	0016266	biological_process	O-glycan processing
A	0016757	molecular_function	glycosyltransferase activity
A	0018242	biological_process	protein O-linked glycosylation via serine
A	0018243	biological_process	protein O-linked glycosylation via threonine
A	0030145	molecular_function	manganese ion binding
A	0030246	molecular_function	carbohydrate binding
A	0032580	cellular_component	Golgi cisterna membrane
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051604	biological_process	protein maturation
B	0000139	cellular_component	Golgi membrane
B	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005795	cellular_component	Golgi stack
B	0006486	biological_process	protein glycosylation
B	0006493	biological_process	protein O-linked glycosylation
B	0016020	cellular_component	membrane
B	0016266	biological_process	O-glycan processing
B	0016757	molecular_function	glycosyltransferase activity
B	0018242	biological_process	protein O-linked glycosylation via serine
B	0018243	biological_process	protein O-linked glycosylation via threonine
B	0030145	molecular_function	manganese ion binding
B	0030246	molecular_function	carbohydrate binding
B	0032580	cellular_component	Golgi cisterna membrane
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051604	biological_process	protein maturation
C	0000139	cellular_component	Golgi membrane
C	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005795	cellular_component	Golgi stack
C	0006486	biological_process	protein glycosylation
C	0006493	biological_process	protein O-linked glycosylation
C	0016020	cellular_component	membrane
C	0016266	biological_process	O-glycan processing
C	0016757	molecular_function	glycosyltransferase activity
C	0018242	biological_process	protein O-linked glycosylation via serine
C	0018243	biological_process	protein O-linked glycosylation via threonine
C	0030145	molecular_function	manganese ion binding
C	0030246	molecular_function	carbohydrate binding
C	0032580	cellular_component	Golgi cisterna membrane
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051604	biological_process	protein maturation
D	0000139	cellular_component	Golgi membrane
D	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005795	cellular_component	Golgi stack
D	0006486	biological_process	protein glycosylation
D	0006493	biological_process	protein O-linked glycosylation
D	0016020	cellular_component	membrane
D	0016266	biological_process	O-glycan processing
D	0016757	molecular_function	glycosyltransferase activity
D	0018242	biological_process	protein O-linked glycosylation via serine
D	0018243	biological_process	protein O-linked glycosylation via threonine
D	0030145	molecular_function	manganese ion binding
D	0030246	molecular_function	carbohydrate binding
D	0032580	cellular_component	Golgi cisterna membrane
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051604	biological_process	protein maturation
E	0000139	cellular_component	Golgi membrane
E	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005795	cellular_component	Golgi stack
E	0006486	biological_process	protein glycosylation
E	0006493	biological_process	protein O-linked glycosylation
E	0016020	cellular_component	membrane
E	0016266	biological_process	O-glycan processing
E	0016757	molecular_function	glycosyltransferase activity
E	0018242	biological_process	protein O-linked glycosylation via serine
E	0018243	biological_process	protein O-linked glycosylation via threonine
E	0030145	molecular_function	manganese ion binding
E	0030246	molecular_function	carbohydrate binding
E	0032580	cellular_component	Golgi cisterna membrane
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051604	biological_process	protein maturation
F	0000139	cellular_component	Golgi membrane
F	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005795	cellular_component	Golgi stack
F	0006486	biological_process	protein glycosylation
F	0006493	biological_process	protein O-linked glycosylation
F	0016020	cellular_component	membrane
F	0016266	biological_process	O-glycan processing
F	0016757	molecular_function	glycosyltransferase activity
F	0018242	biological_process	protein O-linked glycosylation via serine
F	0018243	biological_process	protein O-linked glycosylation via threonine
F	0030145	molecular_function	manganese ion binding
F	0030246	molecular_function	carbohydrate binding
F	0032580	cellular_component	Golgi cisterna membrane
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051604	biological_process	protein maturation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-ARG6
B	MET1-ARG6
C	MET1-ARG6
D	MET1-ARG6
E	MET1-ARG6
F	MET1-ARG6

site_id	SWS_FT_FI2
Number of Residues	102
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
A	MET7-TYR24
B	MET7-TYR24
C	MET7-TYR24
D	MET7-TYR24
E	MET7-TYR24
F	MET7-TYR24

site_id	SWS_FT_FI3
Number of Residues	3276
Details	TOPO_DOM: Lumenal => ECO:0000255

Chain	Residue	Details
A	SER25-GLN571
B	SER25-GLN571
C	SER25-GLN571
D	SER25-GLN571
E	SER25-GLN571
F	SER25-GLN571

site_id	SWS_FT_FI4
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269\|PubMed:16434399, ECO:0000269\|PubMed:24954443, ECO:0000269\|PubMed:25939779, ECO:0007744\|PDB:2FFU, ECO:0007744\|PDB:2FFV, ECO:0007744\|PDB:4D0T, ECO:0007744\|PDB:4D11, ECO:0007744\|PDB:5AJP, ECO:0007744\|PDB:5FV9

Chain	Residue	Details
A	THR143
B	ARG201
B	SER225
B	TRP331
B	ARG362
B	HIS365
C	THR143
C	ASP176
C	ARG201
C	SER225
C	TRP331
A	ASP176
C	ARG362
C	HIS365
D	THR143
D	ASP176
D	ARG201
D	SER225
D	TRP331
D	ARG362
D	HIS365
E	THR143
A	ARG201
E	ASP176
E	ARG201
E	SER225
E	TRP331
E	ARG362
E	HIS365
F	THR143
F	ASP176
F	ARG201
F	SER225
A	SER225
F	TRP331
F	ARG362
F	HIS365
A	TRP331
A	ARG362
A	HIS365
B	THR143
B	ASP176

site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:16434399, ECO:0000269\|PubMed:24954443, ECO:0000269\|PubMed:25939779, ECO:0007744\|PDB:2FFU, ECO:0007744\|PDB:2FFV, ECO:0007744\|PDB:4D0T, ECO:0007744\|PDB:4D0Z, ECO:0007744\|PDB:4D11, ECO:0007744\|PDB:5AJP, ECO:0007744\|PDB:5FV9

Chain	Residue	Details
A	ASP224
D	ASP224
D	HIS226
D	HIS359
E	ASP224
E	HIS226
E	HIS359
F	ASP224
F	HIS226
F	HIS359
A	HIS226
A	HIS359
B	ASP224
B	HIS226
B	HIS359
C	ASP224
C	HIS226
C	HIS359

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:16434399, ECO:0000269\|PubMed:24954443, ECO:0000269\|PubMed:25939779, ECO:0007744\|PDB:2FFU, ECO:0007744\|PDB:2FFV, ECO:0007744\|PDB:4D0T, ECO:0007744\|PDB:4D0Z, ECO:0007744\|PDB:4D11, ECO:0007744\|PDB:5AJN, ECO:0007744\|PDB:5AJO, ECO:0007744\|PDB:5AJP, ECO:0007744\|PDB:5FV9, ECO:0007744\|PDB:5NDF, ECO:0007744\|PDB:6EGS

Chain	Residue	Details
A	TYR367
B	TYR367
C	TYR367
D	TYR367
E	TYR367
F	TYR367

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Not glycosylated

Chain	Residue	Details
A	ASP516
B	ASP516
C	ASP516
D	ASP516
E	ASP516
F	ASP516

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER536
B	SER536
C	SER536
D	SER536
E	SER536
F	SER536

site_id	SWS_FT_FI9
Number of Residues	6
Details	CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269\|PubMed:37453717

Chain	Residue	Details
A	SER29
B	SER29
C	SER29
D	SER29
E	SER29
F	SER29

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)