4CL1
The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NON-STRUCTURAL PROTEIN 5A | polymer | 177 | 19830.6 | 4 | UniProt (K4KA16) Pfam (PF08300) Pfam (PF08301) | HEPATITIS C VIRUS (ISOLATE H77) | P56, NS5A |
| 2 | E, G, H, I (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, B, C, D: 4 - 173 (UniProt: K4KA16)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Asp 174 | - | expression tag |
| Asp 175 | - | expression tag |
| Asp 176 | - | expression tag |
| Asp 177 | - | expression tag |
| Lys 178 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79322.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 357.7 | |
| All* | Total formula weight | 79680.3 |
