4CIM
Complex of a Bcl-w BH3 mutant with a BH3 domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | BCL-2-LIKE PROTEIN 2 | polymer | 163 | 17801.9 | 2 | UniProt (Q92843) Pfam (PF02180) Pfam (PF00452) In PDB | HOMO SAPIENS (HUMAN) | BCL2-L-2, APOPTOSIS REGULATOR BCL-W |
2 | P, Q | BCL-2-LIKE PROTEIN 2 | polymer | 21 | 2336.6 | 2 | UniProt (Q92843) In PDB | HOMO SAPIENS (HUMAN) | BCL2-L-2, APOPTOSIS REGULATOR BCL-W |
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
4 | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 163 (UniProt: Q92843)
P, Q: 38 - 58 (UniProt: Q92843)
PDB | External Database | Details |
---|---|---|
Ser 29 | Cys 29 | engineered mutation |
Gly 43 | His 43 | engineered mutation |
Leu 46 | Met 46 | engineered mutation |
Ile 49 | Ala 49 | engineered mutation |
Glu 128 | Ala 128 | engineered mutation |
Arg 133 | Gln 133 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 43 | His 43 | engineered mutation |
Leu 46 | Met 46 | engineered mutation |
Ile 49 | Ala 49 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 40276.9 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 993.1 | |
All* | Total formula weight | 41270.0 |