4CIM

Complex of a Bcl-w BH3 mutant with a BH3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	BCL-2-LIKE PROTEIN 2	polymer	163	17801.9	2	UniProt (Q92843) Pfam (PF02180) Pfam (PF00452)	HOMO SAPIENS (HUMAN)	BCL2-L-2, APOPTOSIS REGULATOR BCL-W
2	C, D (P, Q)	BCL-2-LIKE PROTEIN 2	polymer	21	2336.6	2	UniProt (Q92843)	HOMO SAPIENS (HUMAN)	BCL2-L-2, APOPTOSIS REGULATOR BCL-W
3	E, F, G, H, I... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
4	U, V, W, X (A, B, P, Q)	water	water		18.0	277	Chemie (HOH)

Sequence modifications

A, B: 1 - 163 (UniProt: Q92843)

PDB	External Database	Details
Ser 29	Cys 29	engineered mutation
Gly 43	His 43	engineered mutation
Leu 46	Met 46	engineered mutation
Ile 49	Ala 49	engineered mutation
Glu 128	Ala 128	engineered mutation
Arg 133	Gln 133	engineered mutation

P, Q: 38 - 58 (UniProt: Q92843)

PDB	External Database	Details
Gly 43	His 43	engineered mutation
Leu 46	Met 46	engineered mutation
Ile 49	Ala 49	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	40276.9
Non-Polymers*	Number of molecules	16
	Total formula weight	993.1
All*	Total formula weight	41270.0

*Water molecules are not included.