4C2S
Crystal structure of the fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA P156L mutant) in complex with UDP and deoxy-H-antigen acceptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE | polymer | 292 | 34063.4 | 2 | UniProt (P16442) Pfam (PF03414) | HOMO SAPIENS (HUMAN) | FUCOSYLGLYCOPROTEIN 3-ALPHA-GALACTOSYLTRANSFERASE, FUCOSYLGLYCOPROTEIN ALPHA-N-ACETYLGALACTOSAMINYLTRANSFERASE, GLYCOPROTEIN-FUCOSYLGALACTOSIDE ALPHA-N-ACETYLGALACTOSAMINYLTRANSFERASE, GLYCOPROTEIN-FUCOSYLGALACTOSIDE ALPHA-GALACTOSYLTRANSFERASE, HISTO-BLOOD GROUP A TRANSFERASE, A TRANSFERASE, HISTO-BLOOD GROUP B TRANSFERASE, B TRANSFERASE, NAGAT, FUCOSYLGLYCOPROTEIN ALPHA-N-ACETYLGALACTOSAMINYLTRANSFERASE SOLUBLE FORM |
| 2 | C, D (C, D) | alpha-L-fucopyranose-(1-2)-hexyl 3-deoxy-beta-D-galactopyranoside | branched | 394.5 | 2 | In PDB GlyTouCan (G50243CR) | |||
| 3 | E, G (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) PubChem (27854) | |||
| 4 | F, H (A, B) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 2 | Chemie (UDP) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (57448939) PubChem (53486216) PubChem (60098857) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) PubChem (1158) PubChem (6031) PubChem (3084486) PubChem (6101632) PubChem (6604175) PubChem (11811538) PubChem (12049241) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A, B: 64 - 354 (UniProt: P16442)
| PDB | External Database | Details |
|---|---|---|
| Met 63 | - | expression tag |
| Leu 156 | Pro 156 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68126.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 788.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 918.2 | |
| All* | Total formula weight | 69833.8 |
