4C1Q
Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9 | polymer | 175 | 19899.0 | 2 | UniProt (Q96EQ9) Pfam (PF21549) | MUS MUSCULUS (HOUSE MOUSE) | PRDM9, HYBRID STERILITY PROTEIN 1, MEIOSIS-INDUCED FACTOR CONTAINING A PR/SET DOMAIN AND ZINC-FINGER MO PR DOMAIN ZINC FINGER PROTEIN 9, PR DOMAIN-CONTAINING PROTEIN 9 |
| 2 | C (C) | HISTONE H3.1 | polymer | 10 | 1253.5 | 1 | UniProt (P68431) | HOMO SAPIENS | HISTONE H3, HISTONE H3/A, HISTONE H3/B, HISTONE H3/C, HISTON HISTONE H3/F, HISTONE H3/H, HISTONE H3/I, HISTONE H3/J, HISTONE H3/K, HISTONE H3/L |
| 3 | D (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A, B: 198 - 368 (UniProt: Q96EQ9)
C: 1 - 10 (UniProt: P68431)
| PDB | External Database | Details |
|---|---|---|
| Gly 194 | - | expression tag |
| Ala 195 | - | expression tag |
| Met 196 | - | expression tag |
| Ser 197 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Tyr 10 | Ser 11 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 41051.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 607.3 | |
| All* | Total formula weight | 41658.9 |
