4C1Q

Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042054	molecular_function	histone methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH A 394

Chain	Residue
A	ILE253
A	TYR361
A	HOH2024
A	HOH2035
C	ARG2
C	MLY4
A	ALA256
A	LEU258
A	TYR291
A	ARG317
A	ASN320
A	CYS321
A	ARG323
A	TYR357

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 493

Chain	Residue
A	CYS205
A	CYS208
A	CYS216
A	HIS219

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 493

Chain	Residue
B	CYS205
B	CYS208
B	CYS216
B	HIS219

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1358

Chain	Residue
B	TYR276
B	GLY290
B	SER292
B	TRP293
B	VAL319

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095733","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C1Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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