4C1Q
Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH A 394 |
| Chain | Residue |
| A | ILE253 |
| A | TYR361 |
| A | HOH2024 |
| A | HOH2035 |
| C | ARG2 |
| C | MLY4 |
| A | ALA256 |
| A | LEU258 |
| A | TYR291 |
| A | ARG317 |
| A | ASN320 |
| A | CYS321 |
| A | ARG323 |
| A | TYR357 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 493 |
| Chain | Residue |
| A | CYS205 |
| A | CYS208 |
| A | CYS216 |
| A | HIS219 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 493 |
| Chain | Residue |
| B | CYS205 |
| B | CYS208 |
| B | CYS216 |
| B | HIS219 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1358 |
| Chain | Residue |
| B | TYR276 |
| B | GLY290 |
| B | SER292 |
| B | TRP293 |
| B | VAL319 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| C | ARG2 | |
| B | CYS205 | |
| B | CYS208 | |
| B | CYS216 | |
| B | HIS219 | |
| B | ALA256 | |
| B | ASN288 | |
| B | TYR291 | |
| B | ASN320 | |
| B | TYR357 | |
| A | CYS208 | |
| A | CYS216 | |
| A | HIS219 | |
| A | ALA256 | |
| A | ASN288 | |
| A | TYR291 | |
| A | ASN320 | |
| A | TYR357 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| C | THR3 | |
| B | LYS368 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | MLY4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| C | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| C | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| C | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| C | TYR10 |
