4BZB
Crystal structure of the tetrameric dGTP-bound SAMHD1 mutant catalytic core
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 | polymer | 550 | 63426.4 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) In PDB | HOMO SAPIENS (HUMAN) | DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1, SAMHD1 |
2 | A, B, C, D | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 12 | Chemie (DGT) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
4 | water | water | 18.0 | 877 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)
PDB | External Database | Details |
---|---|---|
Met 77 | - | expression tag |
Gly 78 | - | expression tag |
Ser 79 | - | expression tag |
Ser 80 | - | expression tag |
His 81 | - | expression tag |
His 82 | - | expression tag |
His 83 | - | expression tag |
His 84 | - | expression tag |
His 85 | - | expression tag |
His 86 | - | expression tag |
Ser 87 | - | expression tag |
Ser 88 | - | expression tag |
Gly 89 | - | expression tag |
Leu 90 | - | expression tag |
Val 91 | - | expression tag |
Pro 92 | - | expression tag |
Arg 93 | - | expression tag |
Gly 94 | - | expression tag |
Ser 95 | - | expression tag |
His 96 | - | expression tag |
Met 97 | - | expression tag |
Ala 98 | - | expression tag |
Ser 99 | - | expression tag |
Met 100 | - | expression tag |
Thr 101 | - | expression tag |
Gly 102 | - | expression tag |
Gly 103 | - | expression tag |
Gln 104 | - | expression tag |
Gln 105 | - | expression tag |
Met 106 | - | expression tag |
Gly 107 | - | expression tag |
Arg 108 | - | expression tag |
Asp 109 | - | expression tag |
Pro 110 | - | expression tag |
Asn 111 | - | expression tag |
Ser 112 | - | expression tag |
Arg 206 | His 206 | engineered mutation |
Asn 207 | Asp 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 253705.5 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 6280.6 | |
All* | Total formula weight | 259986.1 |