4BL5
Crystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | GDP-L-FUCOSE SYNTHASE | polymer | 336 | 37807.6 | 12 | UniProt (Q13630) Pfam (PF01370) | HOMO SAPIENS (HUMAN) | GDP-4-KETO-6-DEOXY-D-MANNOSE-3,5-EPIMERASE-4-REDUCTASE, PROTEIN FX, RED CELL NADP(H)-BINDING PROTEIN, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 4E MEMBER 1 |
| 2 | BA, DA, FA, HA, JA... (H, I, J, K, L...) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 12 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | AA, CA, EA, GA, IA... (G, H, I, J, K...) | GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE | non-polymer | 589.3 | 12 | Chemie (GFB) PubChem (135412609) PubChem (135432122) PubChem (135618130) PubChem (135820750) PubChem (135857542) PubChem (136771500) PubChem (137034801) PubChem (137286751) PubChem (154728870) PubChem (162951224) PubChem (171699380) PubChem (135398578) PubChem (135398655) PubChem (135398688) PubChem (135398715) PubChem (135402013) PubChem (135410864) PubChem (135442158) PubChem (135665286) PubChem (135815440) PubChem (135815442) PubChem (135829314) PubChem (136044550) PubChem (136153884) PubChem (136254584) PubChem (136597497) PubChem (136597502) PubChem (136649460) PubChem (136663939) PubChem (137105976) PubChem (137105977) PubChem (137105978) PubChem (137270783) PubChem (138454237) PubChem (169441079) PubChem (171439195) | |||
| 4 | Y (F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | LA, MA, NA, OA, PA... (A, B, C, D, E...) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 8 - 321 (UniProt: Q13630)
| PDB | External Database | Details |
|---|---|---|
| Met -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Val -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 453691.0 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 16055.0 | |
| All* | Total formula weight | 469746.1 |
