4BL5

Crystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001913	biological_process	T cell mediated cytotoxicity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0007159	biological_process	leukocyte cell-cell adhesion
A	0009055	molecular_function	electron transfer activity
A	0009226	biological_process	nucleotide-sugar biosynthetic process
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0016491	molecular_function	oxidoreductase activity
A	0016853	molecular_function	isomerase activity
A	0019673	biological_process	GDP-mannose metabolic process
A	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
A	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
A	0042802	molecular_function	identical protein binding
A	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
A	0050577	molecular_function	GDP-L-fucose synthase activity
A	0070062	cellular_component	extracellular exosome
A	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
B	0001913	biological_process	T cell mediated cytotoxicity
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0007159	biological_process	leukocyte cell-cell adhesion
B	0009055	molecular_function	electron transfer activity
B	0009226	biological_process	nucleotide-sugar biosynthetic process
B	0010595	biological_process	positive regulation of endothelial cell migration
B	0016491	molecular_function	oxidoreductase activity
B	0016853	molecular_function	isomerase activity
B	0019673	biological_process	GDP-mannose metabolic process
B	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
B	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
B	0042802	molecular_function	identical protein binding
B	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
B	0050577	molecular_function	GDP-L-fucose synthase activity
B	0070062	cellular_component	extracellular exosome
B	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
C	0001913	biological_process	T cell mediated cytotoxicity
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0007159	biological_process	leukocyte cell-cell adhesion
C	0009055	molecular_function	electron transfer activity
C	0009226	biological_process	nucleotide-sugar biosynthetic process
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0016491	molecular_function	oxidoreductase activity
C	0016853	molecular_function	isomerase activity
C	0019673	biological_process	GDP-mannose metabolic process
C	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
C	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
C	0042802	molecular_function	identical protein binding
C	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
C	0050577	molecular_function	GDP-L-fucose synthase activity
C	0070062	cellular_component	extracellular exosome
C	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
D	0001913	biological_process	T cell mediated cytotoxicity
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0007159	biological_process	leukocyte cell-cell adhesion
D	0009055	molecular_function	electron transfer activity
D	0009226	biological_process	nucleotide-sugar biosynthetic process
D	0010595	biological_process	positive regulation of endothelial cell migration
D	0016491	molecular_function	oxidoreductase activity
D	0016853	molecular_function	isomerase activity
D	0019673	biological_process	GDP-mannose metabolic process
D	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
D	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
D	0042802	molecular_function	identical protein binding
D	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
D	0050577	molecular_function	GDP-L-fucose synthase activity
D	0070062	cellular_component	extracellular exosome
D	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
E	0001913	biological_process	T cell mediated cytotoxicity
E	0003824	molecular_function	catalytic activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0007159	biological_process	leukocyte cell-cell adhesion
E	0009055	molecular_function	electron transfer activity
E	0009226	biological_process	nucleotide-sugar biosynthetic process
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0016491	molecular_function	oxidoreductase activity
E	0016853	molecular_function	isomerase activity
E	0019673	biological_process	GDP-mannose metabolic process
E	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
E	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
E	0042802	molecular_function	identical protein binding
E	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
E	0050577	molecular_function	GDP-L-fucose synthase activity
E	0070062	cellular_component	extracellular exosome
E	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
F	0001913	biological_process	T cell mediated cytotoxicity
F	0003824	molecular_function	catalytic activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0007159	biological_process	leukocyte cell-cell adhesion
F	0009055	molecular_function	electron transfer activity
F	0009226	biological_process	nucleotide-sugar biosynthetic process
F	0010595	biological_process	positive regulation of endothelial cell migration
F	0016491	molecular_function	oxidoreductase activity
F	0016853	molecular_function	isomerase activity
F	0019673	biological_process	GDP-mannose metabolic process
F	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
F	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
F	0042802	molecular_function	identical protein binding
F	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
F	0050577	molecular_function	GDP-L-fucose synthase activity
F	0070062	cellular_component	extracellular exosome
F	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
G	0001913	biological_process	T cell mediated cytotoxicity
G	0003824	molecular_function	catalytic activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0007159	biological_process	leukocyte cell-cell adhesion
G	0009055	molecular_function	electron transfer activity
G	0009226	biological_process	nucleotide-sugar biosynthetic process
G	0010595	biological_process	positive regulation of endothelial cell migration
G	0016491	molecular_function	oxidoreductase activity
G	0016853	molecular_function	isomerase activity
G	0019673	biological_process	GDP-mannose metabolic process
G	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
G	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
G	0042802	molecular_function	identical protein binding
G	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
G	0050577	molecular_function	GDP-L-fucose synthase activity
G	0070062	cellular_component	extracellular exosome
G	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
H	0001913	biological_process	T cell mediated cytotoxicity
H	0003824	molecular_function	catalytic activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0007159	biological_process	leukocyte cell-cell adhesion
H	0009055	molecular_function	electron transfer activity
H	0009226	biological_process	nucleotide-sugar biosynthetic process
H	0010595	biological_process	positive regulation of endothelial cell migration
H	0016491	molecular_function	oxidoreductase activity
H	0016853	molecular_function	isomerase activity
H	0019673	biological_process	GDP-mannose metabolic process
H	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
H	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
H	0042802	molecular_function	identical protein binding
H	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
H	0050577	molecular_function	GDP-L-fucose synthase activity
H	0070062	cellular_component	extracellular exosome
H	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
I	0001913	biological_process	T cell mediated cytotoxicity
I	0003824	molecular_function	catalytic activity
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0007159	biological_process	leukocyte cell-cell adhesion
I	0009055	molecular_function	electron transfer activity
I	0009226	biological_process	nucleotide-sugar biosynthetic process
I	0010595	biological_process	positive regulation of endothelial cell migration
I	0016491	molecular_function	oxidoreductase activity
I	0016853	molecular_function	isomerase activity
I	0019673	biological_process	GDP-mannose metabolic process
I	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
I	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
I	0042802	molecular_function	identical protein binding
I	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
I	0050577	molecular_function	GDP-L-fucose synthase activity
I	0070062	cellular_component	extracellular exosome
I	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
J	0001913	biological_process	T cell mediated cytotoxicity
J	0003824	molecular_function	catalytic activity
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0007159	biological_process	leukocyte cell-cell adhesion
J	0009055	molecular_function	electron transfer activity
J	0009226	biological_process	nucleotide-sugar biosynthetic process
J	0010595	biological_process	positive regulation of endothelial cell migration
J	0016491	molecular_function	oxidoreductase activity
J	0016853	molecular_function	isomerase activity
J	0019673	biological_process	GDP-mannose metabolic process
J	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
J	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
J	0042802	molecular_function	identical protein binding
J	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
J	0050577	molecular_function	GDP-L-fucose synthase activity
J	0070062	cellular_component	extracellular exosome
J	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
K	0001913	biological_process	T cell mediated cytotoxicity
K	0003824	molecular_function	catalytic activity
K	0005515	molecular_function	protein binding
K	0005829	cellular_component	cytosol
K	0007159	biological_process	leukocyte cell-cell adhesion
K	0009055	molecular_function	electron transfer activity
K	0009226	biological_process	nucleotide-sugar biosynthetic process
K	0010595	biological_process	positive regulation of endothelial cell migration
K	0016491	molecular_function	oxidoreductase activity
K	0016853	molecular_function	isomerase activity
K	0019673	biological_process	GDP-mannose metabolic process
K	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
K	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
K	0042802	molecular_function	identical protein binding
K	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
K	0050577	molecular_function	GDP-L-fucose synthase activity
K	0070062	cellular_component	extracellular exosome
K	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin
L	0001913	biological_process	T cell mediated cytotoxicity
L	0003824	molecular_function	catalytic activity
L	0005515	molecular_function	protein binding
L	0005829	cellular_component	cytosol
L	0007159	biological_process	leukocyte cell-cell adhesion
L	0009055	molecular_function	electron transfer activity
L	0009226	biological_process	nucleotide-sugar biosynthetic process
L	0010595	biological_process	positive regulation of endothelial cell migration
L	0016491	molecular_function	oxidoreductase activity
L	0016853	molecular_function	isomerase activity
L	0019673	biological_process	GDP-mannose metabolic process
L	0042351	biological_process	'de novo' GDP-L-fucose biosynthetic process
L	0042356	molecular_function	GDP-4-dehydro-D-rhamnose reductase activity
L	0042802	molecular_function	identical protein binding
L	0047918	molecular_function	GDP-mannose 3,5-epimerase activity
L	0050577	molecular_function	GDP-L-fucose synthase activity
L	0070062	cellular_component	extracellular exosome
L	1904906	biological_process	positive regulation of endothelial cell-matrix adhesion via fibronectin

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAP A 901

Chain	Residue
A	GLY14
A	ASP47
A	LEU48
A	LEU69
A	ALA71
A	VAL73
A	CYS112
A	LEU113
A	SER114
A	TYR143
A	LYS147
A	GLY15
A	PRO170
A	THR171
A	VAL173
A	ARG320
A	GFB902
A	SER16
A	GLY17
A	LEU18
A	VAL19
A	SER42
A	SER43
A	ALA46

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GFB A 902

Chain	Residue
A	GLY74
A	GLY75
A	LEU76
A	CYS116
A	ASN140
A	TYR143
A	ASN172
A	GLY185
A	HIS186
A	VAL187
A	LYS194
A	TRP208
A	PRO213
A	ARG215
A	ILE252
A	SER276
A	ASP277
A	LYS282
A	NAP901

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAP B 901

Chain	Residue
B	GLY14
B	SER16
B	GLY17
B	LEU18
B	VAL19
B	SER43
B	ALA46
B	ASP47
B	LEU48
B	LEU69
B	ALA70
B	ALA71
B	VAL73
B	CYS112
B	LEU113
B	SER114
B	TYR143
B	LYS147
B	THR171
B	VAL173
B	HIS186
B	ARG320
B	GFB902

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GFB B 902

Chain	Residue
B	GLY74
B	GLY75
B	LEU76
B	ASN79
B	CYS116
B	ASN140
B	TYR143
B	ASN172
B	GLY185
B	HIS186
B	VAL187
B	LEU191
B	LYS194
B	VAL207
B	TRP208
B	GLY209
B	PRO213
B	ARG215
B	ILE252
B	SER276
B	ASP277
B	LYS282
B	NAP901

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAP C 901

Chain	Residue
C	ALA70
C	ALA71
C	VAL73
C	CYS112
C	LEU113
C	SER114
C	TYR143
C	LYS147
C	THR171
C	VAL173
C	HIS186
C	ARG320
C	GFB902
C	GLY14
C	SER16
C	GLY17
C	LEU18
C	VAL19
C	SER43
C	ALA46
C	ASP47
C	LEU48
C	LEU69

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GFB C 902

Chain	Residue
C	GLY74
C	GLY75
C	LEU76
C	PHE77
C	ASN79
C	SER114
C	CYS116
C	ASN140
C	TYR143
C	ASN172
C	GLY185
C	HIS186
C	VAL187
C	LYS194
C	VAL207
C	TRP208
C	ARG215
C	ILE252
C	SER276
C	ASP277
C	LYS282
C	NAP901
C	HOH2006

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP D 901

Chain	Residue
D	GLY14
D	GLY15
D	SER16
D	GLY17
D	LEU18
D	VAL19
D	SER43
D	ALA46
D	ASP47
D	LEU48
D	LEU69
D	ALA70
D	ALA71
D	VAL73
D	CYS112
D	LEU113
D	SER114
D	TYR143
D	LYS147
D	PRO170
D	THR171
D	VAL173
D	HIS186
D	ARG320
D	GFB902

---

site_id	AC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GFB D 902

Chain	Residue
D	GLY74
D	GLY75
D	LEU76
D	SER114
D	CYS116
D	ASN140
D	TYR143
D	ASN172
D	GLY185
D	HIS186
D	VAL187
D	LYS194
D	TRP208
D	ARG215
D	ILE252
D	SER276
D	ASP277
D	LYS282
D	NAP901

---

site_id	AC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAP E 901

Chain	Residue
E	GLY14
E	SER16
E	GLY17
E	LEU18
E	VAL19
E	SER43
E	ALA46
E	ASP47
E	LEU48
E	LEU69
E	ALA70
E	ALA71
E	VAL73
E	MET93
E	CYS112
E	LEU113
E	TYR143
E	LYS147
E	PRO170
E	THR171
E	VAL173
E	HIS186
E	ARG320
E	GFB902

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GFB E 902

Chain	Residue
E	GLY74
E	GLY75
E	LEU76
E	CYS116
E	ASN140
E	TYR143
E	ASN172
E	GLY185
E	HIS186
E	VAL187
E	LYS194
E	TRP208
E	ARG215
E	SER276
E	ASP277
E	LYS282
E	NAP901
E	HOH2002

---

site_id	BC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAP F 901

Chain	Residue
F	GLY14
F	SER16
F	GLY17
F	LEU18
F	VAL19
F	SER43
F	ALA46
F	ASP47
F	LEU48
F	THR49
F	LEU69
F	ALA70
F	ALA71
F	VAL73
F	CYS112
F	LEU113
F	SER114
F	TYR143
F	LYS147
F	THR171
F	VAL173
F	HIS186
F	ARG320
F	GFB902

---

site_id	BC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GFB F 902

Chain	Residue
F	GLY74
F	GLY75
F	LEU76
F	ASN79
F	SER114
F	CYS116
F	ASN140
F	TYR143
F	ASN172
F	GLY185
F	HIS186
F	VAL187
F	LYS194
F	TRP208
F	GLY209
F	ARG215
F	ILE252
F	SER276
F	ASP277
F	LYS282
F	NAP901

---

site_id	BC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP G 901

Chain	Residue
G	GLY14
G	GLY15
G	SER16
G	GLY17
G	LEU18
G	VAL19
G	SER42
G	SER43
G	ALA46
G	ASP47
G	LEU48
G	LEU69
G	ALA70
G	ALA71
G	VAL73
G	CYS112
G	LEU113
G	SER114
G	TYR143
G	LYS147
G	THR171
G	VAL173
G	HIS186
G	ARG320
G	GFB902

---

site_id	BC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GFB G 902

Chain	Residue
G	GLY74
G	GLY75
G	LEU76
G	ASN79
G	SER114
G	CYS116
G	ASN140
G	TYR143
G	ASN172
G	GLY185
G	HIS186
G	VAL187
G	LEU191
G	LYS194
G	VAL207
G	TRP208
G	GLY209
G	PRO213
G	ARG215
G	ILE252
G	SER276
G	ASP277
G	LYS282
G	NAP901

---

site_id	BC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAP H 901

Chain	Residue
H	GLY14
H	SER16
H	GLY17
H	LEU18
H	VAL19
H	SER43
H	ALA46
H	ASP47
H	LEU48
H	THR49
H	LEU69
H	ALA71
H	VAL73
H	CYS112
H	LEU113
H	TYR143
H	LYS147
H	PRO170
H	THR171
H	VAL173
H	HIS186
H	ARG320
H	GFB902

---

site_id	BC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GFB H 902

Chain	Residue
H	GLY74
H	GLY75
H	LEU76
H	PHE77
H	ASN79
H	CYS116
H	ASN140
H	TYR143
H	ASN172
H	GLY185
H	HIS186
H	VAL187
H	LEU191
H	LYS194
H	VAL207
H	TRP208
H	GLY209
H	PRO213
H	ARG215
H	ILE252
H	SER276
H	ASP277
H	LYS282
H	NAP901

---

site_id	BC8
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAP I 901

Chain	Residue
I	GLY14
I	GLY15
I	SER16
I	GLY17
I	LEU18
I	VAL19
I	SER42
I	SER43
I	ALA46
I	ASP47
I	LEU48
I	LEU69
I	ALA70
I	ALA71
I	VAL73
I	MET93
I	CYS112
I	LEU113
I	SER114
I	TYR143
I	LYS147
I	PRO170
I	THR171
I	VAL173
I	HIS186
I	ARG320
I	GFB902

---

site_id	BC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GFB I 902

Chain	Residue
I	GLY74
I	GLY75
I	LEU76
I	CYS116
I	ASN140
I	TYR143
I	ASN172
I	GLY185
I	HIS186
I	VAL187
I	LEU191
I	LYS194
I	VAL207
I	TRP208
I	GLY209
I	PRO213
I	ARG215
I	ILE252
I	SER276
I	ASP277
I	LYS282
I	NAP901

---

site_id	CC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAP J 901

Chain	Residue
J	GLY14
J	GLY15
J	SER16
J	GLY17
J	LEU18
J	VAL19
J	SER42
J	SER43
J	ALA46
J	ASP47
J	LEU48
J	LEU69
J	ALA70
J	ALA71
J	VAL73
J	CYS112
J	LEU113
J	SER114
J	TYR143
J	LYS147
J	PRO170
J	THR171
J	VAL173
J	HIS186
J	ARG320
J	GFB902

---

site_id	CC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GFB J 902

Chain	Residue
J	GLY74
J	GLY75
J	LEU76
J	PHE77
J	ASN79
J	CYS116
J	ASN140
J	TYR143
J	ASN172
J	GLY185
J	HIS186
J	VAL187
J	LYS194
J	TRP208
J	ARG215
J	ILE252
J	SER276
J	ASP277
J	LYS282
J	NAP901

---

site_id	CC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAP K 901

Chain	Residue
K	GLY14
K	GLY15
K	SER16
K	GLY17
K	LEU18
K	VAL19
K	SER42
K	SER43
K	ALA46
K	ASP47
K	LEU48
K	LEU69
K	ALA70
K	ALA71
K	VAL73
K	MET93
K	CYS112
K	LEU113
K	SER114
K	TYR143
K	LYS147
K	PRO170
K	THR171
K	VAL173
K	HIS186
K	ARG320

---

site_id	CC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GFB K 902

Chain	Residue
K	GLY74
K	GLY75
K	LEU76
K	ASN79
K	CYS116
K	ASN140
K	TYR143
K	ASN172
K	GLY185
K	HIS186
K	VAL187
K	LEU191
K	LYS194
K	VAL207
K	TRP208
K	PRO213
K	ARG215
K	ILE252
K	SER276
K	ASP277
K	LYS282

---

site_id	CC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAP L 901

Chain	Residue
L	GLY14
L	SER16
L	GLY17
L	LEU18
L	VAL19
L	SER42
L	SER43
L	ALA46
L	ASP47
L	LEU48
L	LEU69
L	ALA70
L	ALA71
L	VAL73
L	MET93
L	CYS112
L	LEU113
L	SER114
L	TYR143
L	PRO170
L	THR171
L	VAL173
L	HIS186
L	ARG320
L	GFB902
L	HOH2003

---

site_id	CC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GFB L 902

Chain	Residue
L	GLY74
L	GLY75
L	LEU76
L	CYS116
L	ASN140
L	TYR143
L	ASN172
L	GLY185
L	HIS186
L	VAL187
L	LYS194
L	TRP208
L	GLY209
L	ARG215
L	SER276
L	ASP277
L	LYS282
L	NAP901

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 1321

Chain	Residue
F	THR49
F	THR51
F	HIS92
F	ASN96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23774504","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of human GDP-L-fucose synthase with bound NADP.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of human GDP-L-fucose synthase with bound NADP.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"APR-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of human GDP-L-fucose synthase with bound NADP.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Site: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---