4BKF

crystal structure of the human EphA4 ectodomain in complex with human ephrinB3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	EPHRIN TYPE-A RECEPTOR 4	polymer	568	62679.4	2	UniProt (P54764) Pfam (PF01404) Pfam (PF07699) Pfam (PF00041)	HOMO SAPIENS (HUMAN)	EPH-LIKE KINASE 8, EK8, HEK8, TYROSINE-PROTEIN KINASE TYRO1, TYROSINE-PROTEIN KINASE RECEPTOR SEK
2	C, D (C, D)	EPHRIN-B3	polymer	183	20404.4	2	UniProt (Q15768) Pfam (PF00812)	HOMO SAPIENS (HUMAN)	EPH-RELATED RECEPTOR TRANSMEMBRANE LIGAND ELK-L3, EPH-RELATED RECEPTOR TYROSINE KINASE LIGAND 8, LERK-8

Sequence modifications

A, B: 20 - 547 (UniProt: P54764)

PDB	External Database	Details
Met -11	-	expression tag
Gly -10	-	expression tag
Ile -9	-	expression tag
Leu -8	-	expression tag
Pro -7	-	expression tag
Ser -6	-	expression tag
Pro -5	-	expression tag
Gly -4	-	expression tag
Met -3	-	expression tag
Pro -2	-	expression tag
Ala -1	-	expression tag
Leu 0	-	expression tag
Leu 1	-	expression tag
Ser 2	-	expression tag
Leu 3	-	expression tag
Val 4	-	expression tag
Ser 5	-	expression tag
Leu 6	-	expression tag
Leu 7	-	expression tag
Ser 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Met 12	-	expression tag
Gly 13	-	expression tag
Cys 14	-	expression tag
Val 15	-	expression tag
Ala 16	-	expression tag
Glu 17	-	expression tag
Thr 18	-	expression tag
Gly 19	-	expression tag
Gly 548	-	expression tag
Thr 549	-	expression tag
Lys 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
Thr 28	Ala 28	conflict

C, D: 27 - 169 (UniProt: Q15768)

PDB	External Database	Details
Met -4	-	expression tag
Gly -3	-	expression tag
Ile -2	-	expression tag
Leu -1	-	expression tag
Pro 0	-	expression tag
Ser 1	-	expression tag
Pro 2	-	expression tag
Gly 3	-	expression tag
Met 4	-	expression tag
Pro 5	-	expression tag
Ala 6	-	expression tag
Leu 7	-	expression tag
Leu 8	-	expression tag
Ser 9	-	expression tag
Leu 10	-	expression tag
Val 11	-	expression tag
Ser 12	-	expression tag
Leu 13	-	expression tag
Leu 14	-	expression tag
Ser 15	-	expression tag
Val 16	-	expression tag
Leu 17	-	expression tag
Leu 18	-	expression tag
Met 19	-	expression tag
Gly 20	-	expression tag
Cys 21	-	expression tag
Val 22	-	expression tag
Ala 23	-	expression tag
Glu 24	-	expression tag
Thr 25	-	expression tag
Gly 26	-	expression tag
Gly 170	-	expression tag
Thr 171	-	expression tag
Lys 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
Ser 75	Asn 75	conflict
Glu 85	Gly 85	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	166167.5
All*	Total formula weight	166167.5

*Water molecules are not included.