4BKF

crystal structure of the human EphA4 ectodomain in complex with human ephrinB3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005003	molecular_function	ephrin receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0005003	molecular_function	ephrin receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0016020	cellular_component	membrane
C	0016020	cellular_component	membrane
D	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00790
Number of Residues	21
Details	RECEPTOR_TYR_KIN_V_1 Receptor tyrosine kinase class V signature 1. FqDvGACIALVSVRVfykKCP

Chain	Residue	Details
A	PHE185-PRO205

---

site_id	PS00791
Number of Residues	21
Details	RECEPTOR_TYR_KIN_V_2 Receptor tyrosine kinase class V signature 2. CgaDGEWlv.PIGnClCnaGHE

Chain	Residue	Details
A	CYS247-GLU267

---

site_id	PS01299
Number of Residues	28
Details	EPHRIN_RBD_1 Ephrin receptor-binding (ephrin RBD) domain signature. RFTiKFQeYSPnlwGhEFrshhdYYiiA

Chain	Residue	Details
C	ARG112-ALA139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	358
Details	Domain: {"description":"Eph LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00883","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	222
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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