4B36

Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational Flexibility at the Functional Regions of the Molecule

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	ANGIOGENIN, EOSINOPHIL CATIONIC-RELATED PROTEIN	polymer	126	14523.4	2	UniProt (P03950) UniProt (Q12762) Pfam (PF00074)	HOMO SAPIENS (HUMAN)	RIBONUCLEASE 5, RNASE 5, ANGIOGENIN-EOSINOPHIL DERIVED NEUROTOXIN HYBRID
2	C, D (B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	E, F (A, B)	water	water		18.0	85	Chemie (HOH)

Sequence modifications

A, B: 1 - 83 (UniProt: P03950)

PDB	External Database	Details
Met 0	-	expression tag

A, B: 94 - 125 (UniProt: P03950)
A, B: 84 - 93 (UniProt: Q12762)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29046.9
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	29117.8

*Water molecules are not included.