4B36
Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational Flexibility at the Functional Regions of the Molecule
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1125 |
| Chain | Residue |
| A | ARG32 |
| A | ARG33 |
| B | ARG32 |
| B | ARG33 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1126 |
| Chain | Residue |
| B | HIS13 |
| B | ASN43 |
| B | THR44 |
| B | ARG123 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF |
| Chain | Residue | Details |
| A | CYS39-PHE45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Nucleolar localization signal","evidences":[{"source":"PubMed","id":"7945327","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 564 |
| Chain | Residue | Details |
| A | HIS13 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | LYS40 | electrostatic stabiliser |
| A | HIS116 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 564 |
| Chain | Residue | Details |
| B | HIS13 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| B | LYS40 | electrostatic stabiliser |
| B | HIS116 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
