4AZI
Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BETA-N-ACETYLHEXOSAMINIDASE | polymer | 442 | 49869.0 | 2 | UniProt (P49610) Pfam (PF00728) | STREPTOCOCCUS PNEUMONIAE | GLYCOSIDE HYDROLASE 20 |
| 2 | C, K (A, B) | O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE | non-polymer | 353.3 | 2 | Chemie (OAN) | |||
| 3 | D, E, F, L, M... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | G, H, I, O (A, B) | BROMIDE ION | non-polymer | 79.9 | 4 | Chemie (BR) PubChem (259) | |||
| 5 | J, P, Q (A, B) | BICINE | non-polymer | 163.2 | 3 | Chemie (BCN) PubChem (8761) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 1147 | Chemie (HOH) |
Sequence modifications
A, B: 627 - 1064 (UniProt: P49610)
| PDB | External Database | Details |
|---|---|---|
| Gly 623 | - | expression tag |
| Ser 624 | - | expression tag |
| His 625 | - | expression tag |
| Met 626 | - | expression tag |
| Trp 913 | Gly 913 | engineered mutation |
| Tyr 914 | Gly 914 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 99738.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1888.2 | |
| All* | Total formula weight | 101626.2 |
