4AQE
CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2S70P AND PROTOCADHERIN-15 EC1-2 FORM I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CADHERIN-23 | polymer | 214 | 23866.5 | 1 | UniProt (Q99PF4) Pfam (PF00028) | MUS MUSCULUS (HOUSE MOUSE) | OTOCADHERIN |
| 2 | B (B) | PROTOCADHERIN-15 | polymer | 242 | 27502.6 | 1 | UniProt (Q99PJ1) Pfam (PF18432) Pfam (PF00028) | MUS MUSCULUS (HOUSE MOUSE) | |
| 3 | C, D, E, F, H... (A, B) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) | |||
| 4 | G (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | K (B) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 403 | Chemie (HOH) |
Sequence modifications
A: 2 - 206 (UniProt: Q99PF4)
B: 1 - 233 (UniProt: Q99PJ1)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Leu 207 | - | expression tag |
| Glu 208 | - | expression tag |
| His 209 | - | expression tag |
| His 210 | - | expression tag |
| His 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| Pro 48 | Ser 70 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Leu 234 | - | expression tag |
| Glu 235 | - | expression tag |
| His 236 | - | expression tag |
| His 237 | - | expression tag |
| His 238 | - | expression tag |
| His 239 | - | expression tag |
| His 240 | - | expression tag |
| His 241 | - | expression tag |
| Tyr 8 | Phe 34 | SEE REMARK 999 |
| Asp 10 | Asn 36 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51369.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 514.9 | |
| All* | Total formula weight | 51884.0 |
