4AP2
Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | KELCH-LIKE PROTEIN 11 | polymer | 297 | 34526.2 | 1 | UniProt (Q9NVR0) Pfam (PF00651) Pfam (PF07707) | HOMO SAPIENS (HUMAN) | |
| 2 | B (B) | CULLIN-3 | polymer | 410 | 48193.9 | 1 | UniProt (Q13618) Pfam (PF00888) | HOMO SAPIENS (HUMAN) | CUL-3 |
| 3 | C, F, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | D (A) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 5 | E (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 67 - 340 (UniProt: Q9NVR0)
B: 1 - 388 (UniProt: Q13618)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| His 48 | - | expression tag |
| His 49 | - | expression tag |
| His 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Ser 52 | - | expression tag |
| Gly 53 | - | expression tag |
| Val 54 | - | expression tag |
| Asp 55 | - | expression tag |
| Leu 56 | - | expression tag |
| Gly 57 | - | expression tag |
| Thr 58 | - | expression tag |
| Glu 59 | - | expression tag |
| Asn 60 | - | expression tag |
| Leu 61 | - | expression tag |
| Tyr 62 | - | expression tag |
| Phe 63 | - | expression tag |
| Gln 64 | - | expression tag |
| Ser 65 | - | expression tag |
| Met 66 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 389 | - | expression tag |
| Glu 390 | - | expression tag |
| Asn 391 | - | expression tag |
| Leu 392 | - | expression tag |
| Tyr 393 | - | expression tag |
| Phe 394 | - | expression tag |
| Gln 395 | - | expression tag |
| Ser 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| Asp 403 | - | expression tag |
| Tyr 404 | - | expression tag |
| Lys 405 | - | expression tag |
| Asp 406 | - | expression tag |
| Asp 407 | - | expression tag |
| Asp 408 | - | expression tag |
| Asp 409 | - | expression tag |
| Lys 410 | - | expression tag |
| Arg 342 | Ile 342 | engineered mutation |
| Asp 346 | Leu 346 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82720.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 410.6 | |
| All* | Total formula weight | 83130.7 |
