4AJC
3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with alpha-ketoglutarate, calcium(II) and adenine nucleotide phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADP ISOCITRATE DEHYDROGENASE | polymer | 416 | 45811.6 | 1 | UniProt (Q1RD16) Pfam (PF00180) UniProt (by SIFTS) (P08200) | ESCHERICHIA COLI | |
| 2 | B (A) | ADENOSINE-2'-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (A2P) | |||
| 3 | C (A) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (A) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A: 1 - 416 (UniProt: Q1RD16)
| PDB | External Database | Details |
|---|---|---|
| Met 100 | Lys 100 | engineered mutation |
| Asp 398 | Glu 398 | conflict |
| Glu 414 | Lys 414 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45811.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 709.4 | |
| All* | Total formula weight | 46521.0 |
