Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0022900 | biological_process | electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE A2P A 501 |
| Chain | Residue |
| A | ARG292 |
| A | TYR391 |
| A | ASP392 |
| A | HOH2358 |
| A | HOH2366 |
| A | HOH2424 |
| A | HOH2425 |
| A | HOH2426 |
| A | HIS339 |
| A | GLY340 |
| A | THR341 |
| A | ALA342 |
| A | LYS344 |
| A | TYR345 |
| A | VAL351 |
| A | ASN352 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AKG A 502 |
| Chain | Residue |
| A | SER113 |
| A | ASN115 |
| A | ARG119 |
| A | ARG129 |
| A | ARG153 |
| A | TYR160 |
| A | LYS230 |
| A | ASN232 |
| A | ILE233 |
| A | ASP307 |
| A | CA503 |
| A | HOH2168 |
| A | HOH2287 |
| A | HOH2428 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | ASP283 |
| A | ASP307 |
| A | ASP311 |
| A | AKG502 |
| A | HOH2169 |
| A | HOH2350 |
| A | HOH2429 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | VAL107 |
| A | GLY108 |
| A | GLY109 |
| A | GLY110 |
| A | LYS235 |
| A | HOH2138 |
| A | HOH2143 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYiSDalAaqv.GGIGI |
| Chain | Residue | Details |
| A | ASN303-ILE322 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10623532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CW4","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 7 |
| Chain | Residue | Details |
| A | TYR160 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | LYS230 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| A | ASP283 | electrostatic stabiliser, proton acceptor, proton donor |
| A | ASP307 | metal ligand |
