4ACS
Crystal structure of mutant GST A2-2 with enhanced catalytic efficiency with azathioprine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | GLUTATHIONE S-TRANSFERASE A2 | polymer | 222 | 25627.7 | 4 | UniProt (P09210) Pfam (PF02798) Pfam (PF00043) In PDB | HOMO SAPIENS (HUMAN) | GST HA SUBUNIT 2, GST CLASS-ALPHA MEMBER 2, GST-GAMMA, GSTA2-2, GTH2 |
2 | A, B, C, D | GLUTATHIONE | non-polymer | 307.3 | 4 | Chemie (GSH) | |||
3 | water | water | 18.0 | 515 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 221 (UniProt: P09210)
PDB | External Database | Details |
---|---|---|
Gly 107 | Leu 107 | engineered mutation |
Asp 108 | Leu 108 | engineered mutation |
Ser 110 | Pro 110 | conflict |
His 222 | Phe 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 102511.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1229.3 | |
All* | Total formula weight | 103740.2 |