4ACS
Crystal structure of mutant GST A2-2 with enhanced catalytic efficiency with azathioprine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | GLUTATHIONE S-TRANSFERASE A2 | polymer | 222 | 25627.7 | 4 | UniProt (P09210) Pfam (PF02798) Pfam (PF00043) | HOMO SAPIENS (HUMAN) | GST HA SUBUNIT 2, GST CLASS-ALPHA MEMBER 2, GST-GAMMA, GSTA2-2, GTH2 |
| 2 | E, F, G, H (A, B, C, D) | GLUTATHIONE | non-polymer | 307.3 | 4 | Chemie (GSH) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 515 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 221 (UniProt: P09210)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | Leu 107 | engineered mutation |
| Asp 108 | Leu 108 | engineered mutation |
| Ser 110 | Pro 110 | conflict |
| His 222 | Phe 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102511.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1229.3 | |
| All* | Total formula weight | 103740.2 |
