4ACS
Crystal structure of mutant GST A2-2 with enhanced catalytic efficiency with azathioprine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0006805 | biological_process | xenobiotic metabolic process |
| C | 0030855 | biological_process | epithelial cell differentiation |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0006805 | biological_process | xenobiotic metabolic process |
| D | 0030855 | biological_process | epithelial cell differentiation |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GSH A 230 |
| Chain | Residue |
| A | TYR9 |
| A | HOH2052 |
| A | HOH2179 |
| A | HOH2180 |
| B | ASP101 |
| B | ARG131 |
| A | ARG45 |
| A | GLN54 |
| A | VAL55 |
| A | PRO56 |
| A | GLN67 |
| A | THR68 |
| A | PHE220 |
| A | HOH2016 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GSH B 230 |
| Chain | Residue |
| A | ASP101 |
| A | ARG131 |
| B | TYR9 |
| B | GLN54 |
| B | VAL55 |
| B | PRO56 |
| B | GLN67 |
| B | THR68 |
| B | PHE220 |
| B | HOH2047 |
| B | HOH2110 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GSH C 230 |
| Chain | Residue |
| C | TYR9 |
| C | ARG45 |
| C | GLN54 |
| C | VAL55 |
| C | PRO56 |
| C | GLN67 |
| C | THR68 |
| C | PHE220 |
| C | HOH2012 |
| C | HOH2118 |
| D | ASP101 |
| D | ARG131 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH D 230 |
| Chain | Residue |
| C | ASP101 |
| C | ARG131 |
| D | TYR9 |
| D | ARG45 |
| D | GLN54 |
| D | VAL55 |
| D | GLN67 |
| D | THR68 |
| D | PHE220 |
| D | HOH2042 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 488 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20083122","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
