4A63

Crystal structure of the p73-ASPP2 complex at 2.6A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	TUMOUR PROTEIN 73	polymer	208	23342.6	6	UniProt (O15350) Pfam (PF00870)	HOMO SAPIENS (HUMAN)	P53-LIKE TRANSCRIPTION FACTOR, P53-RELATED PROTEIN
2	B, D, F, H, J... (B, D, F, H, J...)	APOPTOSIS STIMULATING OF P53 PROTEIN 2	polymer	239	26951.5	6	UniProt (Q13625) Pfam (PF00023) Pfam (PF00018)	HOMO SAPIENS (HUMAN)	BCL2-BINDING PROTEIN, BBP, RENAL CARCINOMA ANTIGEN NY-REN-51,TUMOR SUPPRESSOR P53-BINDING PROTEIN 2,53BP2, P53-BINDING PROTEIN 2, P53BP2
3	M, Q, R, T, W (C, E, G, I, K)	ZINC ION	non-polymer		65.4	5	Chemie (ZN)
4	N, O, P, S, U... (C, G, I, K, L)	ACETATE ION	non-polymer		59.0	9	Chemie (ACT)
5	AA, BA, CA, DA, EA... (B, C, D, E, F...)	water	water		18.0	671	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K: 112 - 311 (UniProt: O15350)

PDB	External Database	Details
Met 111	-	expression tag
Ala 312	-	expression tag
Glu 313	-	expression tag
Asn 314	-	expression tag
Leu 315	-	expression tag
Tyr 316	-	expression tag
Phe 317	-	expression tag
Gln 318	-	expression tag

B, D, F, H, J, L: 892 - 1128 (UniProt: Q13625)

PDB	External Database	Details
Ser 890	-	expression tag
Met 891	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	301764.2
Non-Polymers*	Number of molecules	14
	Total formula weight	858.4
All*	Total formula weight	302622.7

*Water molecules are not included.