4A63

Crystal structure of the p73-ASPP2 complex at 2.6A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
B	0002039	molecular_function	p53 binding
B	0042981	biological_process	regulation of apoptotic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
D	0002039	molecular_function	p53 binding
D	0042981	biological_process	regulation of apoptotic process
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006915	biological_process	apoptotic process
F	0002039	molecular_function	p53 binding
F	0042981	biological_process	regulation of apoptotic process
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006915	biological_process	apoptotic process
H	0002039	molecular_function	p53 binding
H	0042981	biological_process	regulation of apoptotic process
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005634	cellular_component	nucleus
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006915	biological_process	apoptotic process
J	0002039	molecular_function	p53 binding
J	0042981	biological_process	regulation of apoptotic process
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0003677	molecular_function	DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0005634	cellular_component	nucleus
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006915	biological_process	apoptotic process
L	0002039	molecular_function	p53 binding
L	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS194
C	HIS197
C	CYS258
C	CYS262

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 1319

Chain	Residue
C	PRO122
C	HIS126
C	GLU128
C	ARG288

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 1320

Chain	Residue
C	GLU313
I	SER117
I	THR119
I	TYR121
I	ARG287
C	TYR309

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 1321

Chain	Residue
C	SER117
C	THR119
C	TYR121
C	ARG287
I	TYR309
I	GLU313

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS194
E	HIS197
E	CYS258
E	CYS262

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	CYS194
G	HIS197
G	CYS258
G	CYS262

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT G 1319

Chain	Residue
G	SER117
G	THR119
G	TYR121
G	ARG287
G	TYR309
G	GLU313

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1

Chain	Residue
I	CYS194
I	HIS197
I	CYS258
I	CYS262

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT I 1319

Chain	Residue
I	TYR121
I	GLY123

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT I 1320

Chain	Residue
I	ASP120
I	VAL129
I	TYR144
I	LYS149
I	SER289
I	HOH2012
I	HOH2022

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 1

Chain	Residue
K	CYS194
K	HIS197
K	CYS258
K	CYS262

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT K 1319

Chain	Residue
A	TYR309
K	SER117
K	THR119
K	TYR121
K	ARG287

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT K 1320

Chain	Residue
K	ASP120
K	VAL129
K	TYR144
K	LYS149
K	SER289

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT L 1522

Chain	Residue
K	SER261
K	CYS295
K	ALA296
L	GLU1096

---

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCVGGMNRR

Chain	Residue	Details
A	MET257-ARG269

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1074
Details	Region: {"description":"DNA-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	186
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	192
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	198
Details	Repeat: {"description":"ANK 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	252
Details	Repeat: {"description":"ANK 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	372
Details	Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---