3ZNI
Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I, M | E3 UBIQUITIN-PROTEIN LIGASE CBL-B | polymer | 394 | 45748.3 | 4 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) In PDB | HOMO SAPIENS (HUMAN) | CASITAS B-LINEAGE LYMPHOMA PROTO-ONCOGENE B, RING FINGER PROTEIN 56, SH3-BINDING PROTEIN CBL-B, SIGNAL TRANSDUCTION PROTEIN CBL-B |
| 2 | B, F, J, N | TYROSINE-PROTEIN KINASE ZAP-70 | polymer | 12 | 1344.3 | 4 | UniProt (P43403) In PDB | HOMO SAPIENS | 70 KDA ZETA-CHAIN ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE |
| 3 | C, G, K, O | UBIQUITIN-CONJUGATING ENZYME E2 D2 | polymer | 146 | 16720.2 | 4 | UniProt (P62837) Pfam (PF00179) In PDB | HOMO SAPIENS (HUMAN) | UBIQUITIN CARRIER PROTEIN D2, UBIQUITIN-CONJUGATING ENZYME E2(17)KB 2, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2, UBIQUITIN-PROTEIN LIGASE D2, UBCH5B, P53-REGULATED UBIQUITIN-CONJUGATING ENZYME 1 |
| 4 | D, H, L, P | POLYUBIQUITIN-C | polymer | 81 | 8922.1 | 4 | UniProt (P0CG48) Pfam (PF00240) In PDB | HOMO SAPIENS (HUMAN) | UBIQUITIN |
| 5 | M, A, E, I | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 6 | I, M, A, E | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | I, M, A, E | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 8 | water | water | 18.0 | 760 | Chemie (HOH) |
Sequence modifications
A, E, I, M: 36 - 427 (UniProt: Q13191)
C, G, K, O: 2 - 147 (UniProt: P62837)
D, H, L, P: 1 - 76 (UniProt: P0CG48)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | - | expression tag |
| Ser 35 | - | expression tag |
| Phe 360 | Tyr 360 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 22 | Ser 22 | engineered mutation |
| Lys 85 | Cys 85 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 290939.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 931.9 | |
| All* | Total formula weight | 291871.4 |
