3ZNI
Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0023051 | biological_process | regulation of signaling |
| A | 0046872 | molecular_function | metal ion binding |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0036211 | biological_process | protein modification process |
| C | 0051865 | biological_process | protein autoubiquitination |
| C | 0061630 | molecular_function | ubiquitin protein ligase activity |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070936 | biological_process | protein K48-linked ubiquitination |
| E | 0001784 | molecular_function | phosphotyrosine residue binding |
| E | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0007166 | biological_process | cell surface receptor signaling pathway |
| E | 0023051 | biological_process | regulation of signaling |
| E | 0046872 | molecular_function | metal ion binding |
| G | 0000209 | biological_process | protein polyubiquitination |
| G | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005654 | cellular_component | nucleoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| G | 0016567 | biological_process | protein ubiquitination |
| G | 0032991 | cellular_component | protein-containing complex |
| G | 0036211 | biological_process | protein modification process |
| G | 0051865 | biological_process | protein autoubiquitination |
| G | 0061630 | molecular_function | ubiquitin protein ligase activity |
| G | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0070936 | biological_process | protein K48-linked ubiquitination |
| I | 0001784 | molecular_function | phosphotyrosine residue binding |
| I | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| I | 0005509 | molecular_function | calcium ion binding |
| I | 0007166 | biological_process | cell surface receptor signaling pathway |
| I | 0023051 | biological_process | regulation of signaling |
| I | 0046872 | molecular_function | metal ion binding |
| K | 0000209 | biological_process | protein polyubiquitination |
| K | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005654 | cellular_component | nucleoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| K | 0016567 | biological_process | protein ubiquitination |
| K | 0032991 | cellular_component | protein-containing complex |
| K | 0036211 | biological_process | protein modification process |
| K | 0051865 | biological_process | protein autoubiquitination |
| K | 0061630 | molecular_function | ubiquitin protein ligase activity |
| K | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| K | 0070062 | cellular_component | extracellular exosome |
| K | 0070936 | biological_process | protein K48-linked ubiquitination |
| M | 0001784 | molecular_function | phosphotyrosine residue binding |
| M | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| M | 0005509 | molecular_function | calcium ion binding |
| M | 0007166 | biological_process | cell surface receptor signaling pathway |
| M | 0023051 | biological_process | regulation of signaling |
| M | 0046872 | molecular_function | metal ion binding |
| O | 0000209 | biological_process | protein polyubiquitination |
| O | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| O | 0005515 | molecular_function | protein binding |
| O | 0005654 | cellular_component | nucleoplasm |
| O | 0005829 | cellular_component | cytosol |
| O | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| O | 0016567 | biological_process | protein ubiquitination |
| O | 0032991 | cellular_component | protein-containing complex |
| O | 0036211 | biological_process | protein modification process |
| O | 0051865 | biological_process | protein autoubiquitination |
| O | 0061630 | molecular_function | ubiquitin protein ligase activity |
| O | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| O | 0070062 | cellular_component | extracellular exosome |
| O | 0070936 | biological_process | protein K48-linked ubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1428 |
| Chain | Residue |
| A | CYS373 |
| A | CYS376 |
| A | CYS393 |
| A | CYS396 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1429 |
| Chain | Residue |
| A | CYS388 |
| A | HIS390 |
| A | CYS408 |
| A | CYS411 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1428 |
| Chain | Residue |
| E | CYS376 |
| E | CYS393 |
| E | CYS396 |
| E | CYS373 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1429 |
| Chain | Residue |
| E | CYS388 |
| E | HIS390 |
| E | CYS408 |
| E | CYS411 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN I 1427 |
| Chain | Residue |
| I | CYS373 |
| I | CYS376 |
| I | CYS393 |
| I | CYS396 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN I 1428 |
| Chain | Residue |
| I | CYS388 |
| I | HIS390 |
| I | CYS408 |
| I | CYS411 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN M 1428 |
| Chain | Residue |
| M | CYS373 |
| M | CYS376 |
| M | CYS393 |
| M | CYS396 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN M 1429 |
| Chain | Residue |
| M | CYS388 |
| M | HIS390 |
| M | CYS408 |
| M | CYS411 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1430 |
| Chain | Residue |
| A | ASP221 |
| A | THR223 |
| A | ASN225 |
| A | TYR227 |
| A | GLU232 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 1430 |
| Chain | Residue |
| E | ASP221 |
| E | THR223 |
| E | ASN225 |
| E | TYR227 |
| E | GLU232 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA I 1429 |
| Chain | Residue |
| I | ASP221 |
| I | THR223 |
| I | ASN225 |
| I | TYR227 |
| I | GLU232 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA M 1430 |
| Chain | Residue |
| M | ASP221 |
| M | THR223 |
| M | ASN225 |
| M | TYR227 |
| M | GLU232 |
| M | HOH2041 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 1431 |
| Chain | Residue |
| E | PHE231 |
| E | ASP234 |
| E | ARG238 |
| E | LEU292 |
| E | GLU414 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1431 |
| Chain | Residue |
| A | PHE231 |
| A | ASP234 |
| A | ARG238 |
| A | LEU292 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO I 1430 |
| Chain | Residue |
| I | PHE231 |
| I | ASP234 |
| I | ARG238 |
| I | LEU292 |
| I | HOH2056 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO M 1431 |
| Chain | Residue |
| M | PHE231 |
| M | ASP234 |
| M | ARG238 |
| M | LEU292 |
| M | HOH2072 |
| M | HOH2111 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 288 |
| Details | Region: {"description":"EF-hand-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 408 |
| Details | Region: {"description":"SH2-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P22681","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCQ","evidences":[{"source":"PubMed","id":"19549985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"20525694","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8943331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 300 |
| Details | Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
