3ZNI

Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005509	molecular_function	calcium ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0032991	cellular_component	protein-containing complex
C	0036211	biological_process	protein modification process
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
E	0001784	molecular_function	phosphotyrosine residue binding
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005509	molecular_function	calcium ion binding
E	0007166	biological_process	cell surface receptor signaling pathway
E	0023051	biological_process	regulation of signaling
E	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000209	biological_process	protein polyubiquitination
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016567	biological_process	protein ubiquitination
G	0016740	molecular_function	transferase activity
G	0032991	cellular_component	protein-containing complex
G	0036211	biological_process	protein modification process
G	0051865	biological_process	protein autoubiquitination
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0061631	molecular_function	ubiquitin conjugating enzyme activity
G	0070062	cellular_component	extracellular exosome
G	0070936	biological_process	protein K48-linked ubiquitination
I	0001784	molecular_function	phosphotyrosine residue binding
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005509	molecular_function	calcium ion binding
I	0007166	biological_process	cell surface receptor signaling pathway
I	0023051	biological_process	regulation of signaling
I	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000209	biological_process	protein polyubiquitination
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0032991	cellular_component	protein-containing complex
K	0036211	biological_process	protein modification process
K	0051865	biological_process	protein autoubiquitination
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061631	molecular_function	ubiquitin conjugating enzyme activity
K	0070062	cellular_component	extracellular exosome
K	0070936	biological_process	protein K48-linked ubiquitination
M	0001784	molecular_function	phosphotyrosine residue binding
M	0004842	molecular_function	ubiquitin-protein transferase activity
M	0005509	molecular_function	calcium ion binding
M	0007166	biological_process	cell surface receptor signaling pathway
M	0023051	biological_process	regulation of signaling
M	0046872	molecular_function	metal ion binding
O	0000166	molecular_function	nucleotide binding
O	0000209	biological_process	protein polyubiquitination
O	0004842	molecular_function	ubiquitin-protein transferase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0016567	biological_process	protein ubiquitination
O	0016740	molecular_function	transferase activity
O	0032991	cellular_component	protein-containing complex
O	0036211	biological_process	protein modification process
O	0051865	biological_process	protein autoubiquitination
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0061631	molecular_function	ubiquitin conjugating enzyme activity
O	0070062	cellular_component	extracellular exosome
O	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1428

Chain	Residue
A	CYS373
A	CYS376
A	CYS393
A	CYS396

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1429

Chain	Residue
A	CYS388
A	HIS390
A	CYS408
A	CYS411

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1428

Chain	Residue
E	CYS376
E	CYS393
E	CYS396
E	CYS373

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1429

Chain	Residue
E	CYS388
E	HIS390
E	CYS408
E	CYS411

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1427

Chain	Residue
I	CYS373
I	CYS376
I	CYS393
I	CYS396

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1428

Chain	Residue
I	CYS388
I	HIS390
I	CYS408
I	CYS411

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 1428

Chain	Residue
M	CYS373
M	CYS376
M	CYS393
M	CYS396

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 1429

Chain	Residue
M	CYS388
M	HIS390
M	CYS408
M	CYS411

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1430

Chain	Residue
A	ASP221
A	THR223
A	ASN225
A	TYR227
A	GLU232

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 1430

Chain	Residue
E	ASP221
E	THR223
E	ASN225
E	TYR227
E	GLU232

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 1429

Chain	Residue
I	ASP221
I	THR223
I	ASN225
I	TYR227
I	GLU232

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 1430

Chain	Residue
M	ASP221
M	THR223
M	ASN225
M	TYR227
M	GLU232
M	HOH2041

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 1431

Chain	Residue
E	PHE231
E	ASP234
E	ARG238
E	LEU292
E	GLU414

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1431

Chain	Residue
A	PHE231
A	ASP234
A	ARG238
A	LEU292

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 1430

Chain	Residue
I	PHE231
I	ASP234
I	ARG238
I	LEU292
I	HOH2056

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO M 1431

Chain	Residue
M	PHE231
M	ASP234
M	ARG238
M	LEU292
M	HOH2072
M	HOH2111

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
D	LYS27-ASP52

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS388-LEU397

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	288
Details	Region: {"description":"EF-hand-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	408
Details	Region: {"description":"SH2-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P22681","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCQ","evidences":[{"source":"PubMed","id":"19549985","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"20525694","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8943331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	300
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---