3WMH

Human PPAR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor gamma	polymer	286	32530.7	2	UniProt (P37231) Pfam (PF00104)	Homo sapiens (human)	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2	C, D (A, B)	N-(phenylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide	non-polymer		530.6	2	Chemie (JJA)
3	E, F (A, B)	water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B: 195 - 476 (UniProt: P37231)

PDB	External Database	Details
Gly 191	-	expression tag
Ser 192	-	expression tag
His 193	-	expression tag
Met 194	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65061.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1061.2
All*	Total formula weight	66122.5

*Water molecules are not included.