3VA2

Crystal structure of human Interleukin-5 in complex with its alpha receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-5	polymer	119	13374.3	2	UniProt (P05113) Pfam (PF02025)	Homo sapiens (human)	IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
2	C (C)	Interleukin-5 receptor subunit alpha	polymer	322	36393.7	1	UniProt (Q01344) Pfam (PF09240)	Homo sapiens (human)	IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125
3	D, E, F (A, B, C)	water	water		18.0	32	Chemie (HOH)

Sequence modifications

A, B: 23 - 134 (UniProt: P05113)

PDB	External Database	Details
Gly 16	-	expression tag
Ser 17	-	expression tag
Ser 18	-	expression tag
Gly 19	-	expression tag
Ser 20	-	expression tag
Ser 21	-	expression tag
Gly 22	-	expression tag

C: 21 - 335 (UniProt: Q01344)

PDB	External Database	Details
Gly 14	-	expression tag
Ser 15	-	expression tag
Ser 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Gly 20	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	63142.3
All*	Total formula weight	63142.3

*Water molecules are not included.