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3VA2

Crystal structure of human Interleukin-5 in complex with its alpha receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0002639biological_processpositive regulation of immunoglobulin production
A0005125molecular_functioncytokine activity
A0005137molecular_functioninterleukin-5 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0019221biological_processcytokine-mediated signaling pathway
A0030890biological_processpositive regulation of B cell proliferation
A0038043biological_processinterleukin-5-mediated signaling pathway
A0045645biological_processpositive regulation of eosinophil differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0071803biological_processpositive regulation of podosome assembly
B0002639biological_processpositive regulation of immunoglobulin production
B0005125molecular_functioncytokine activity
B0005137molecular_functioninterleukin-5 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0019221biological_processcytokine-mediated signaling pathway
B0030890biological_processpositive regulation of B cell proliferation
B0038043biological_processinterleukin-5-mediated signaling pathway
B0045645biological_processpositive regulation of eosinophil differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0071803biological_processpositive regulation of podosome assembly
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS01356
Number of Residues30
DetailsHEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. LhCtWlvGtdapeDtqYfLyyrygswtee....C
ChainResidueDetails
CLEU153-CYS182

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN35
CASN131
CASN216
CASN244

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:2361960
ChainResidueDetails
AASN47
BASN47

218853

PDB entries from 2024-04-24

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