3VA2

Crystal structure of human Interleukin-5 in complex with its alpha receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002639	biological_process	positive regulation of immunoglobulin production
A	0005125	molecular_function	cytokine activity
A	0005137	molecular_function	interleukin-5 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030890	biological_process	positive regulation of B cell proliferation
A	0038043	biological_process	interleukin-5-mediated signaling pathway
A	0045645	biological_process	positive regulation of eosinophil differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0071803	biological_process	positive regulation of podosome assembly
B	0002639	biological_process	positive regulation of immunoglobulin production
B	0005125	molecular_function	cytokine activity
B	0005137	molecular_function	interleukin-5 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
B	0008083	molecular_function	growth factor activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030890	biological_process	positive regulation of B cell proliferation
B	0038043	biological_process	interleukin-5-mediated signaling pathway
B	0045645	biological_process	positive regulation of eosinophil differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0071803	biological_process	positive regulation of podosome assembly
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01356
Number of Residues	30
Details	HEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. LhCtWlvGtdapeDtqYfLyyrygswtee....C

Chain	Residue	Details
C	LEU153-CYS182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"2361960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2361960","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	91
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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