3UWP

Crystal structure of Dot1l in complex with 5-iodotubercidin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase, H3 lysine-79 specific	polymer	438	50124.0	1	UniProt (Q8TEK3) Pfam (PF08123)	Homo sapiens (human)	DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4
2	B (A)	(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL	non-polymer		392.1	1	Chemie (5ID)
3	C, D (A)	IODIDE ION	non-polymer		126.9	2	Chemie (IOD)
4	E (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	F, G, H, I, J... (A)	UNKNOWN ATOM OR ION	non-polymer			6	Chemie (UNX)
6	L (A)	water	water		18.0	66	Chemie (HOH)

Sequence modifications

A: 1 - 420 (UniProt: Q8TEK3)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50124.0
Non-Polymers*	Number of molecules	10
	Total formula weight	668.9
All*	Total formula weight	50793.0

*Water molecules are not included.