3UWP

Crystal structure of Dot1l in complex with 5-iodotubercidin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 5ID A 421

Chain	Residue
A	TYR58
A	IOD422
A	GLU129
A	GLY163
A	GLU186
A	LYS187
A	GLY221
A	ASP222
A	PHE223
A	ASN241

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 422

Chain	Residue
A	5ID421

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 423

Chain	Residue
A	GLY246
A	VAL249

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 424

Chain	Residue
A	LYS52
A	LEU53
A	MET55
A	ASN57
A	HOH480
A	HOH481

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	314
Details	Domain: {"description":"DOT1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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