3ULU
Structure of quaternary complex of human TLR3ecd with three Fabs (Form1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Toll-like receptor 3 | polymer | 694 | 78794.6 | 1 | UniProt (O15455) Pfam (PF13855) Pfam (PF13516) Pfam (PF00560) In PDB | Homo sapiens (human) | TLR3ecd |
| 2 | L | Fab15 light chain | polymer | 214 | 23239.8 | 1 | Homo sapiens (human) | ||
| 3 | H | Fab15 heavy chain | polymer | 225 | 24458.3 | 1 | Homo sapiens (human) | ||
| 4 | C | Fab12 light chain | polymer | 213 | 22749.9 | 1 | Homo sapiens (human) | ||
| 5 | D | Fab12 heavy chain | polymer | 226 | 24575.4 | 1 | Homo sapiens (human) | ||
| 6 | E | Fab1068 light chain | polymer | 215 | 23606.1 | 1 | Homo sapiens (human) | ||
| 7 | F | Fab1068 heavy chain | polymer | 223 | 24302.3 | 1 | Homo sapiens (human) | ||
| 8 | B, G, I, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 9 | K | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 10 | M | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 11 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 12 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A: 22 - 702 (UniProt: O15455)
| PDB | External Database | Details |
|---|---|---|
| Ala 17 | - | cloning artifact |
| Asp 18 | - | cloning artifact |
| Leu 19 | - | cloning artifact |
| Gly 20 | - | cloning artifact |
| Ser 21 | - | cloning artifact |
| Ala 703 | - | expression tag |
| Ser 704 | - | expression tag |
| His 705 | - | expression tag |
| His 706 | - | expression tag |
| His 707 | - | expression tag |
| His 708 | - | expression tag |
| His 709 | - | expression tag |
| His 710 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 221726.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3032.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1202.1 | |
| All* | Total formula weight | 225961.4 |
