3T5G
Structure of fully modified farnesylated Rheb in complex with PDE6D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTP-binding protein Rheb | polymer | 181 | 20248.1 | 1 | UniProt (Q15382) Pfam (PF00071) | Homo sapiens (human) | Ras homolog enriched in brain |
| 2 | B (B) | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | polymer | 152 | 17585.1 | 1 | UniProt (O43924) Pfam (PF05351) | Homo sapiens (human) | GMP-PDE delta, Protein p17 |
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | FARNESYL | non-polymer | 206.4 | 1 | Chemie (FAR) PubChem (21734683) PubChem (444108) PubChem (22820188) PubChem (56993491) PubChem (4475483) PubChem (13619421) PubChem (158605953) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 416 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: Q15382)
B: 1 - 150 (UniProt: O43924)
| PDB | External Database | Details |
|---|---|---|
| Cys 174 | Ala 174 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37833.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 673.9 | |
| All* | Total formula weight | 38507.1 |
