3T5G
Structure of fully modified farnesylated Rheb in complex with PDE6D
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003924 | molecular_function | GTPase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005681 | cellular_component | spliceosomal complex |
A | 0005737 | cellular_component | cytoplasm |
A | 0005764 | cellular_component | lysosome |
A | 0005765 | cellular_component | lysosomal membrane |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0007165 | biological_process | signal transduction |
A | 0007264 | biological_process | small GTPase-mediated signal transduction |
A | 0012505 | cellular_component | endomembrane system |
A | 0014069 | cellular_component | postsynaptic density |
A | 0016020 | cellular_component | membrane |
A | 0016241 | biological_process | regulation of macroautophagy |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019003 | molecular_function | GDP binding |
A | 0019901 | molecular_function | protein kinase binding |
A | 0030295 | molecular_function | protein kinase activator activity |
A | 0031669 | biological_process | cellular response to nutrient levels |
A | 0032006 | biological_process | regulation of TOR signaling |
A | 0032008 | biological_process | positive regulation of TOR signaling |
A | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
A | 0045202 | cellular_component | synapse |
A | 0046872 | molecular_function | metal ion binding |
A | 0048709 | biological_process | oligodendrocyte differentiation |
A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0070062 | cellular_component | extracellular exosome |
A | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
A | 1904263 | biological_process | positive regulation of TORC1 signaling |
A | 2000074 | biological_process | regulation of type B pancreatic cell development |
B | 0005095 | molecular_function | GTPase inhibitor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005929 | cellular_component | cilium |
B | 0007601 | biological_process | visual perception |
B | 0016020 | cellular_component | membrane |
B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
B | 0031267 | molecular_function | small GTPase binding |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0042995 | cellular_component | cell projection |
B | 0050953 | biological_process | sensory perception of light stimulus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE GDP A 201 |
Chain | Residue |
A | SER16 |
A | ASP122 |
A | LEU123 |
A | SER149 |
A | ALA150 |
A | LYS151 |
A | HOH197 |
A | MG202 |
A | HOH212 |
A | HOH288 |
A | HOH294 |
A | VAL17 |
A | HOH298 |
A | HOH304 |
A | HOH362 |
A | HOH395 |
A | HOH434 |
A | HOH449 |
A | GLY18 |
A | LYS19 |
A | SER20 |
A | SER21 |
A | PHE31 |
A | ASN119 |
A | LYS120 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 202 |
Chain | Residue |
A | SER20 |
A | GDP201 |
A | HOH395 |
A | HOH396 |
A | HOH434 |
A | HOH449 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE FAR A 2010 |
Chain | Residue |
A | SER180 |
A | CMT181 |
B | MET20 |
B | LEU38 |
B | ILE53 |
B | GLN78 |
B | TYR149 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:1XTS, ECO:0007744|PDB:6BCU |
Chain | Residue | Details |
A | SER16 | |
A | GLY18 | |
A | TYR35 | |
A | ASN119 | |
A | ASP122 | |
A | ALA150 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:32470140, ECO:0007744|PDB:1XTQ, ECO:0007744|PDB:3SEA, ECO:0007744|PDB:3T5G, ECO:0007744|PDB:7BTA, ECO:0007744|PDB:7BTC |
Chain | Residue | Details |
A | VAL17 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:1XTS, ECO:0007744|PDB:6BCU |
Chain | Residue | Details |
A | LYS19 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0007744|PDB:5YXH, ECO:0007744|PDB:6BCU, ECO:0007744|PDB:6BSX, ECO:0007744|PDB:6BT0 |
Chain | Residue | Details |
A | SER20 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0007744|PDB:1XTS |
Chain | Residue | Details |
A | SER21 | |
A | VAL32 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0007744|PDB:3SEA, ECO:0007744|PDB:6BT0, ECO:0007744|PDB:7BTA, ECO:0007744|PDB:7BTC |
Chain | Residue | Details |
A | ASP33 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:6BCU |
Chain | Residue | Details |
A | THR38 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Important for autoinhibition of GTPase activity => ECO:0000269|PubMed:22819219 |
Chain | Residue | Details |
A | TYR35 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000250|UniProtKB:Q921J2 |
Chain | Residue | Details |
A | SER130 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15308774, ECO:0000269|PubMed:22002721, ECO:0007744|PDB:3T5G |
Chain | Residue | Details |
A | CMT181 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | LIPID: S-farnesyl cysteine => ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15308774, ECO:0000269|PubMed:22002721, ECO:0007744|PDB:3T5G |
Chain | Residue | Details |
A | CMT181 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30514904 |
Chain | Residue | Details |
A | LYS8 |