3T3Z

Human Cytochrome P450 2E1 in complex with pilocarpine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Cytochrome P450 2E1	polymer	476	55058.5	4	UniProt (P05181) Pfam (PF00067)	Homo sapiens (human)	4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-J
2	E, F, G, H (E, F, G, H)	beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose	branched		342.3	4	In PDB BIRD (PRD_900003)		sucrose
3	I, K, M, O (A, B, C, D)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
4	J, L, N, P (A, B, C, D)	(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one	non-polymer		208.3	4	Chemie (9PL)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	714	Chemie (HOH)

Sequence modifications

A, B, C, D: 32 - 493 (UniProt: P05181)

PDB	External Database	Details
Met 22	-	expression tag
Ala 23	-	expression tag
Lys 24	-	expression tag
Lys 25	-	expression tag
Thr 26	-	expression tag
Ser 27	-	expression tag
Ser 28	-	expression tag
Lys 29	-	expression tag
Gly 30	-	expression tag
Lys 31	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	220234.0
Branched	Number of molecules	4
	Total formula weight	1369.2
Non-Polymers*	Number of molecules	8
	Total formula weight	3299.0
All*	Total formula weight	224902.1

*Water molecules are not included.