3T3Z

Human Cytochrome P450 2E1 in complex with pilocarpine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001676	biological_process	long-chain fatty acid metabolic process
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006631	biological_process	fatty acid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008392	molecular_function	arachidonic acid epoxygenase activity
A	0009617	biological_process	response to bacterium
A	0016098	biological_process	monoterpenoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0018601	molecular_function	4-nitrophenol 2-monooxygenase activity
A	0018885	biological_process	carbon tetrachloride metabolic process
A	0018910	biological_process	benzene metabolic process
A	0018960	biological_process	4-nitrophenol metabolic process
A	0019373	biological_process	epoxygenase P450 pathway
A	0019825	molecular_function	oxygen binding
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0030544	molecular_function	Hsp70 protein binding
A	0042197	biological_process	halogenated hydrocarbon metabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0051879	molecular_function	Hsp90 protein binding
A	0070330	molecular_function	aromatase activity
A	0120319	molecular_function	long-chain fatty acid omega-1 hydroxylase activity
B	0001676	biological_process	long-chain fatty acid metabolic process
B	0002933	biological_process	lipid hydroxylation
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006631	biological_process	fatty acid metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008392	molecular_function	arachidonic acid epoxygenase activity
B	0009617	biological_process	response to bacterium
B	0016098	biological_process	monoterpenoid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0018601	molecular_function	4-nitrophenol 2-monooxygenase activity
B	0018885	biological_process	carbon tetrachloride metabolic process
B	0018910	biological_process	benzene metabolic process
B	0018960	biological_process	4-nitrophenol metabolic process
B	0019373	biological_process	epoxygenase P450 pathway
B	0019825	molecular_function	oxygen binding
B	0019899	molecular_function	enzyme binding
B	0020037	molecular_function	heme binding
B	0030544	molecular_function	Hsp70 protein binding
B	0042197	biological_process	halogenated hydrocarbon metabolic process
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046872	molecular_function	metal ion binding
B	0051879	molecular_function	Hsp90 protein binding
B	0070330	molecular_function	aromatase activity
B	0120319	molecular_function	long-chain fatty acid omega-1 hydroxylase activity
C	0001676	biological_process	long-chain fatty acid metabolic process
C	0002933	biological_process	lipid hydroxylation
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006631	biological_process	fatty acid metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008392	molecular_function	arachidonic acid epoxygenase activity
C	0009617	biological_process	response to bacterium
C	0016098	biological_process	monoterpenoid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
C	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C	0018601	molecular_function	4-nitrophenol 2-monooxygenase activity
C	0018885	biological_process	carbon tetrachloride metabolic process
C	0018910	biological_process	benzene metabolic process
C	0018960	biological_process	4-nitrophenol metabolic process
C	0019373	biological_process	epoxygenase P450 pathway
C	0019825	molecular_function	oxygen binding
C	0019899	molecular_function	enzyme binding
C	0020037	molecular_function	heme binding
C	0030544	molecular_function	Hsp70 protein binding
C	0042197	biological_process	halogenated hydrocarbon metabolic process
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046872	molecular_function	metal ion binding
C	0051879	molecular_function	Hsp90 protein binding
C	0070330	molecular_function	aromatase activity
C	0120319	molecular_function	long-chain fatty acid omega-1 hydroxylase activity
D	0001676	biological_process	long-chain fatty acid metabolic process
D	0002933	biological_process	lipid hydroxylation
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006631	biological_process	fatty acid metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008392	molecular_function	arachidonic acid epoxygenase activity
D	0009617	biological_process	response to bacterium
D	0016098	biological_process	monoterpenoid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
D	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D	0018601	molecular_function	4-nitrophenol 2-monooxygenase activity
D	0018885	biological_process	carbon tetrachloride metabolic process
D	0018910	biological_process	benzene metabolic process
D	0018960	biological_process	4-nitrophenol metabolic process
D	0019373	biological_process	epoxygenase P450 pathway
D	0019825	molecular_function	oxygen binding
D	0019899	molecular_function	enzyme binding
D	0020037	molecular_function	heme binding
D	0030544	molecular_function	Hsp70 protein binding
D	0042197	biological_process	halogenated hydrocarbon metabolic process
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046872	molecular_function	metal ion binding
D	0051879	molecular_function	Hsp90 protein binding
D	0070330	molecular_function	aromatase activity
D	0120319	molecular_function	long-chain fatty acid omega-1 hydroxylase activity

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FStGKRVCAG

Chain	Residue	Details
A	PHE430-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ALA299
B	ALA299
C	ALA299
D	ALA299

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
A	ALA438
B	ALA438
C	ALA438
D	ALA438

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