3T1I

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Double-strand break repair protein MRE11A	polymer	431	49824.8	4	UniProt (P49959) Pfam (PF00149) Pfam (PF04152) In PDB	Homo sapiens (human)	Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A
2	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
3	A	2,3-DIHYDROXY-1,4-DITHIOBUTANE	non-polymer		154.3	2	Chemie (DTT)
4	D, A, C	GLYCEROL	non-polymer		92.1	15	Chemie (GOL)
5		water	water		18.0	66	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 411 (UniProt: P49959)

PDB	External Database	Details
Mse -19	-	EXPRESSION TAG
Gly -18	-	EXPRESSION TAG
Ser -17	-	EXPRESSION TAG
Ser -16	-	EXPRESSION TAG
His -15	-	EXPRESSION TAG
His -14	-	EXPRESSION TAG
His -13	-	EXPRESSION TAG
His -12	-	EXPRESSION TAG
His -11	-	EXPRESSION TAG
His -10	-	EXPRESSION TAG
Ser -9	-	EXPRESSION TAG
Ser -8	-	EXPRESSION TAG
Gly -7	-	EXPRESSION TAG
Leu -6	-	EXPRESSION TAG
Val -5	-	EXPRESSION TAG
Pro -4	-	EXPRESSION TAG
Arg -3	-	EXPRESSION TAG
Gly -2	-	EXPRESSION TAG
Ser -1	-	EXPRESSION TAG
His 0	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	199299.3
Non-Polymers*	Number of molecules	25
	Total formula weight	2129.4
All*	Total formula weight	201428.7

*Water molecules are not included.