3SXR
Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytoplasmic tyrosine-protein kinase BMX | polymer | 268 | 31210.0 | 2 | UniProt (P51813) Pfam (PF07714) | Homo sapiens (human) | Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase, ETK, NTK38 |
| 2 | C, E (A, B) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 2 | Chemie (1N1) | |||
| 3 | D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B: 411 - 675 (UniProt: P51813)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| His 409 | - | expression tag |
| Met 410 | - | expression tag |
| Lys 432 | Gln 432 | engineered mutation |
| Met 611 | Gln 611 | engineered mutation |
| Thr 617 | Asp 617 | engineered mutation |
| Glu 620 | Gln 620 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62420.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1264.2 | |
| All* | Total formula weight | 63684.3 |
