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3SPA

Crystal Structure of Human Mitochondrial RNA Polymerase

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
DNA-directed RNA polymerase, mitochondrialpolymer1134128736.01UniProt (O00411)
Pfam (PF14700)
Pfam (PF00940)
Homo sapiens (human)MtRPOL
2B
(B)
Nonamer peptidepolymer9784.01Homo sapiens (human)
3C, D
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
4E, F, G, H, I
(A)
CHLORIDE IONnon-polymer35.55Chemie (CL)
5J
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
6K
(A)
waterwater18.0145Chemie (HOH)
Sequence modifications
A: 105 - 1230 (UniProt: O00411)
PDBExternal DatabaseDetails
Met 97-expression tag
Gly 98-expression tag
His 99-expression tag
His 100-expression tag
His 101-expression tag
His 102-expression tag
His 103-expression tag
His 104-expression tag
Ala 555Glu 555engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight129520.0
Non-Polymers*Number of molecules8
Total formula weight457.5
All*Total formula weight129977.5
*Water molecules are not included.

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PDB entries from 2025-06-18

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