3SPA
Crystal Structure of Human Mitochondrial RNA Polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000428 | cellular_component | DNA-directed RNA polymerase complex |
| A | 0001018 | molecular_function | mitochondrial promoter sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003896 | molecular_function | DNA primase activity |
| A | 0003899 | molecular_function | DNA-directed 5'-3' RNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006390 | biological_process | mitochondrial transcription |
| A | 0006391 | biological_process | transcription initiation at mitochondrial promoter |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0034245 | cellular_component | mitochondrial DNA-directed RNA polymerase complex |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1 |
| Chain | Residue |
| A | GLY730 |
| A | PRO732 |
| A | GLU778 |
| A | ALA779 |
| A | ARG782 |
| A | VAL820 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | GLU826 |
| A | HOH1296 |
| A | ARG708 |
| A | VAL709 |
| A | GLY711 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1231 |
| Chain | Residue |
| A | GLY830 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1232 |
| Chain | Residue |
| A | MET406 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | LYS402 |
| A | ARG792 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 4 |
| Chain | Residue |
| A | LEU408 |
| A | ALA409 |
| A | ARG518 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 5 |
| Chain | Residue |
| A | ARG858 |
| A | SER908 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1233 |
| Chain | Residue |
| A | LYS853 |
| A | SER924 |
| A | ARG987 |
| A | LYS991 |
| A | HOH1242 |
Functional Information from PROSITE/UniProt
| site_id | PS00489 |
| Number of Residues | 15 |
| Details | RNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTvvY |
| Chain | Residue | Details |
| A | ILE985-TYR999 |
| site_id | PS00900 |
| Number of Residues | 12 |
| Details | RNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGSCNGLQ |
| Chain | Residue | Details |
| A | PRO918-GLN929 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP922 | |
| A | LYS991 | |
| A | ASP1151 |
