3SI8

Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2)

Replaces:  3MR4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA polymerase eta	polymer	435	48617.7	1	UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) In PDB	Homo sapiens (human)	RAD30 homolog A, Xeroderma pigmentosum variant type protein
2	T	DNA (5'-D(*TP*A*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*C)-3')	polymer	12	3950.6	1
3	P	DNA (5'-D(*TP*GP*CP*GP*TP*CP*AP*TP*A)-3')	polymer	9	2730.8	1
4	A	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine	non-polymer		490.2	1	Chemie (DZ4)
5	A	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
6	A	(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol	non-polymer		251.2	1	Chemie (3D1)
7	A	2,3-DIHYDROXY-1,4-DITHIOBUTANE	non-polymer		154.3	2	Chemie (DTT)
8	A	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
9	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
10	A	COBALT (II) ION	non-polymer		58.9	1	Chemie (CO)
11		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A: 1 - 432 (UniProt: Q9Y253)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55299.1
Non-Polymers*	Number of molecules	20
	Total formula weight	2204.6
All*	Total formula weight	57503.7

*Water molecules are not included.