3SI8
Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2)
Replaces: 3MR4Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase eta | polymer | 435 | 48617.7 | 1 | UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) | Homo sapiens (human) | RAD30 homolog A, Xeroderma pigmentosum variant type protein |
| 2 | B (T) | DNA (5'-D(*TP*A*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*C)-3') | polymer | 12 | 3950.6 | 1 | |||
| 3 | C (P) | DNA (5'-D(*TP*GP*CP*GP*TP*CP*AP*TP*A)-3') | polymer | 9 | 2730.8 | 1 | |||
| 4 | D (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 490.2 | 1 | Chemie (DZ4) | |||
| 5 | E, F, G, H, J... (A) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 6 | I (A) | (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol | non-polymer | 251.2 | 1 | Chemie (3D1) | |||
| 7 | N, O (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 2 | Chemie (DTT) | |||
| 8 | P, Q, R, S, T (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 9 | U, V (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 10 | W (A) | COBALT (II) ION | non-polymer | 58.9 | 1 | Chemie (CO) | |||
| 11 | X, Y, Z (A, T, P) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 55299.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2204.6 | |
| All* | Total formula weight | 57503.7 |
