3SI8

Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2)

Replaces:  3MR4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DZ4 A 433

Chain	Residue
A	ASP13
A	ARG61
A	ASP115
A	LYS231
A	MG450
A	MG451
A	HOH475
A	HOH495
P	DA9
T	TTD5
A	MET14
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ALA49
A	TYR52
A	ARG55

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 434

Chain	Residue
A	HIS240
A	GLY241
A	PRO244
A	EDO449

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 435

Chain	Residue
A	THR282
A	SER284
A	HOH460

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 436

Chain	Residue
A	THR353
A	ASN357

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 437

Chain	Residue
A	LEU11
A	GLU116
A	LYS224
A	CYS227
A	GLY228
A	LYS231
A	HOH495
P	DA9

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3D1 A 438

Chain	Residue
A	SER257
A	LEU262
A	LYS293
A	ASN294
A	TRP297

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 439

Chain	Residue
A	ASP181
A	ASN182
A	LEU183
A	GLN280
A	GLN285

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 440

Chain	Residue
A	VAL372
A	ASP375
A	ARG377

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 441

Chain	Residue
A	ASP140
A	LYS168

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 442

Chain	Residue
A	SER265
A	HIS289
A	PHE290
A	GLN343
A	GLN346
A	EDO447

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DTT A 443

Chain	Residue
A	GLN287
A	GLY291
A	GLU292
A	GLU335
A	TRP339

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DTT A 444

Chain	Residue
A	GLU148
A	GLY149
A	TRP174
A	SER239
A	SER242
A	EDO445

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 445

Chain	Residue
A	GLN152
A	SER177
A	DTT444

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 446

Chain	Residue
A	LYS224
A	ARG253
A	ARG256
P	DT8
P	DA9

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 447

Chain	Residue
A	GOL442

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 448

Chain	Residue
A	ARG253
A	GLY260

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 449

Chain	Residue
A	HIS240
A	ARG303
A	GOL434

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 450

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	DZ4433
A	MG451

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 451

Chain	Residue
A	ASP13
A	ASP115
A	GLU116
A	DZ4433
A	MG450
A	HOH495
P	DA9

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO A 452

Chain	Residue
A	ASP181
A	HIS289
A	HIS393
A	HIS397

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO

Chain	Residue	Details
A	GLU116
A	MET14
A	ASP115
A	ASP13

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197

Chain	Residue	Details
A	ARG61

---