3S9D
binary complex between IFNa2 and IFNAR2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Interferon alpha-2 | polymer | 168 | 19393.2 | 2 | UniProt (P01563) Pfam (PF00143) | Homo sapiens (human) | IFN-alpha-2, Interferon alpha-A, LeIF A |
| 2 | B, D (B, D) | Interferon alpha/beta receptor 2 | polymer | 199 | 22798.0 | 2 | UniProt (P48551) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | IFN-R-2, IFN-alpha binding protein, IFN-alpha/beta receptor 2, Interferon alpha binding protein, Type I interferon receptor 2 |
| 3 | E (D) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 165 (UniProt: P01563)
B, D: 10 - 205 (UniProt: P48551)
| PDB | External Database | Details |
|---|---|---|
| Ala -2 | - | cloning artifact |
| Asp -1 | - | cloning artifact |
| Pro 0 | - | cloning artifact |
| Arg 23 | Lys 46 | conflict |
| Ala 57 | His 80 | engineered mutation |
| Ala 58 | Glu 81 | engineered mutation |
| Ala 61 | Gln 84 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | cloning artifact |
| Asp 8 | - | cloning artifact |
| Pro 9 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 84382.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 84417.9 |
